Results 81 to 90 of about 12,683 (169)

Machine Learning Predicts Treatment Response and Prognostic Pathways From Whole‐Blood Transcriptome in Primary Biliary Cholangitis

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims Prognostic biomarkers that link disease progression and/or responses to therapeutic interventions in patients with primary biliary cholangitis (PBC) remain undefined. In this study, we used a machine learning (ML) approach with whole‐blood transcriptomic data to predict clinical outcomes in response to obeticholic acid (OCA)
Hussain Syed, Ning Sun, Doaa Waly, Varinder Verma, Matthew Smith, David Shapiro, Mary Erickson, Kathy Siminovitch, Mark Swain, Mohammed S. Osman, Andrew L. Mason   +10 more
wiley   +1 more source

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, Volume 251, Issue 3, Page 975-995, August 2026.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

Molecular recognition in plant root endosymbiosis

The Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY Root endosymbiosis is one of the most intimate types of plant–microbe interactions in which a symbiont is hosted within a living plant cell. In this symbiosis, nitrogen‐fixing bacteria and arbuscular mycorrhizal fungi support plant nutrient provisioning in exchange for carbohydrates and lipids.
Tora Fougner‐Økland, Maria Spezzati, Katarzyna Parys   +2 more
wiley   +1 more source

Novel compound heterozygous MVK variants cause early-onset mevalonic aciduria in a Chinese infant

Frontiers in Pediatrics
Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory disorder caused by mevalonate kinase (MVK) gene mutations, with phenotypes ranging from mild hyper-IgD syndrome (HIDS) to severe mevalonic aciduria (MA).
Na Li, Weining Li, HongXia Zhang, Xingcui Wang   +3 more
doaj   +1 more source

Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency. [PDF]

Glob Pediatr Health, 2023
Souali M, Sakhi A, Bousfiha AA, Bouayed K.   +3 more
europepmc   +1 more source

Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer

Frontiers in Pharmacology
IntroductionStatins, widely used for hypercholesterolemia, have shown anticancer properties including induction of apoptosis and ferroptosis, modulation of autophagy, and reprogramming of the tumor microenvironment, making them potential candidates for ...
Francisco Alejandro Lagunas-Rangel, Francisco Alejandro Lagunas-Rangel, Jörgen Jonsson, Ludmila Jackevica, Robert Fredriksson, Maija Dambrova, Maija Dambrova, Helgi B. Schiöth, Helgi B. Schiöth   +8 more
doaj   +1 more source

Early-onset generalized linear porokeratosis with cutaneous squamous cell carcinomas: A case report and genomic analysis

Dermatologica Sinica
Previous studies have shown that porokeratosis (PK) arises from mutations in the enzyme-encoding genes – mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase (MVD), farnesyl diphosphate synthase, and farnesyl-diphosphate ...
Yike Huang, Ying Qi, Zhen Tian, Qiaoan Zhang, Ou Fang, Jia Chen, Jing Luan, Caihua Li, Zhengwen Jiang, Lixiong Gu, Xiaodong Chen, Zhenghua Zhang   +11 more
doaj   +1 more source

Two Siblings With Recurrent Fevers: The Path to Mevalonate Kinase Deficiency Diagnosis. [PDF]

Cureus, 2023
Pereira-Nunes J, Ferreras C, Grangeia A, Aguiar F, Rodrigues M, Brito I.   +5 more
europepmc   +1 more source

Case Report: Early-onset mevalonic aciduria in neonates with inflammatory marker elevated

Frontiers in Immunology
PurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory ...
Shanshan Xue, Shanshan Xue, Wujuan Shi, Wujuan Shi, Xiaobo He, Xiaobo He, Lihong Hao, Lihong Hao   +7 more
doaj   +1 more source

Mevalonate kinase gene polymorphisms in ankylosing spondylitis patients: A cross-sectional study. [PDF]

Arch Rheumatol, 2023
Yıldız F, Dinkçi S, Erken E.
europepmc   +1 more source