Results 91 to 100 of about 22,445 (200)

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]

, 2006
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway ...
M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye, S Séronie-Vivien, MJ Rogers, JR Green, D Amin, JD Bergstrom, K Thompson, E van Beek, HL Benford, SP Luckman, T Iguchi, JE Fisher, K Sawada, C Denoyelle, FP Coxon, ER Van Beek, GM Oades, SG Senaratne, SS Virtanen, F Saad, MR Smith, S Boissier, MV Lee, EC Lerner, TF McGuire, O Cussenot, P Skehan, AB Awad, E Corey, DC Crick, RB Lobell, SA Holstein, SE Ownby, C Allal, JE Dunford, JE Fisher   +40 more
core   +2 more sources

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers, Isabel O. de Moya Clark, Tomás Cavaco, Vivian Nemanič, Beatrice Tagliabue, Ainhoa Valero‐Abad, Wiebe M. Wennekers, Mengqiu Zhang, Koen Van Zwet, Sanne Abeln, Sofia Moco, Caroline E. Paul, Halima Mouhib, Richard A. Notebaart, Eddy J. Smid, Bas Teusink, Herwig Bachmann   +16 more
wiley   +1 more source

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

Advanced Science, Volume 13, Issue 23, 23 April 2026.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai, Zhuoying Huang, Haonan Lin, Guangrui Ding, Hongjian He, Menna Siddiqui, Meng Zhang, Wilson Wong, Ji‐Xin Cheng   +8 more
wiley   +1 more source

Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis [PDF]

, 2015
Metabolic changes can influence inflammatory responses to bacteria. To examine whether localized manipulation of the mevalonate pathway impacts innate immunity, we exploited a unique mucosal disease model, endometritis, where inflammation is a ...
Bonnett, Christine Collier, David G. Smith, Gareth D. Healey, Hans-Joachim Schuberth, I. Martin Sheldon, Ireland, Isabelle Dieuzy-Labaye, Keller, Mital, Olivier Sandra, Petras, Sholeem Griffin, Sinensky, Suman Mahan   +14 more
core   +2 more sources

Mevalonate kinase deficiency (hyper IgD syndrome with periodic fever)--different faces with separate treatments: two cases and review of the literature

The Turkish Journal of Pediatrics, 2012
The hyperimmunoglobulinemia D syndrome (HIDS), so-called mevalonate kinase deficiency, is caused by recessive mutations in the gene encoding mevalonate kinase enzyme.
Pınar Gençpınar, Balahan B Makay, Marco Gattorno, Francesco Caroli, Erbil Ünsal   +4 more
doaj  

Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta

Journal of Lipid Research, 1973
Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey, Gene C. Ness, Nilofer Qureshi, John W. Porter   +3 more
doaj   +1 more source

Putative modifier genes in mevalonate kinase deficiency

Molecular Medicine Reports, 2016
Mevalonate kinase deficiency (MKD) is an autosomal recessive auto‑inflammatory disease, caused by impairment of the mevalonate pathway. Although the molecular mechanism remains to be elucidated, there is clinical evidence suggesting that other regulatory genes may be involved in determining the phenotype.
MARCUZZI, ANNALISA, VOZZI, DIEGO, GIRARDELLI, MARTINA, TRICARICO, PAOLA MAURA, Knowles, Alessandra, CROVELLA, SERGIO, VUCH, JOSEF, TOMMASINI, ALBERTO, PISCIANZ, ELISA, BIANCO, ANNA MONICA ROSARIA   +9 more
openaire   +4 more sources

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes [PDF]

, 2016
The mevalonate pathway is of important clinical, pharmaceutical, and biotechnological relevance. However, lack of the understanding of the phosphorylation mechanism of the kinases in this pathway has limited rationally engineering the kinases in industry.
Hu, Guixiiang, Huang, Meilan, Li, Xiao, McClory, James, Timson, David J., Wei, Kexin, Zou, Jian-Wei   +6 more
core   +4 more sources

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells [PDF]

, 2015
Targeted anticancer therapies represent the most effective pharmacological strategies in terms of clinical responses. In this context, genetic alteration of several oncogenes represents an optimal predictor of response to targeted therapy. Integration of
Anderlucci, Laura, Beneventano, Domenico, Bicciato, Silvio, Caroli, Jimmy, Del Sal, Giannino, Lolli, Marco, Sorrentino, Giovanni, Taccioli, Cristian, Zannini, Alessandro   +8 more
core   +4 more sources

The putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene [PDF]

, 2015
Mevalonate diphosphate decarboxylase (MVD) is an ATP-dependent enzyme that catalyzes the phosphorylation/decarboxylation of (R)-mevalonate-5-diphosphate to isopentenyl pyrophosphate in the mevalonate (MVA) pathway.MVD is a key enzyme in engineered ...
A. M. Spormann, Gill Stephens, Global Bioenergies, Graham Eastham, Luca Rossoni, Organization for Economic Cooperation and Development, Peter Licence, Stephen J. Hall, UniProt Consortium   +8 more
core   +3 more sources