Results 91 to 100 of about 13,572 (204)
Journal of Lipid Research, 1973 Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey +3 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Combined fractional CO2 laser + MTX may be an option for refractory GPK, with vigilant biopsy confirmation and malignancy surveillance.
Ali Asilian +4 more
wiley +1 more source
The Inhibition of Mevalonic Kinase by Geranyl and Farnesyl Pyrophosphates
Journal of Biological Chemistry, 1968 Abstract The inhibition in vitro of a highly purified preparation of mevalonate kinase by terpenyl pyrophosphates has been studied. Geranyl-PP and farnesyl-PP are potent inhibitors, while isopentenyl-PP, dimethylallyl-PP, and inorganic pyrophosphate do not inhibit significantly.
J K, Dorsey, J W, Porter
openaire +2 more sources
eFood, Volume 7, Issue 3, June 2026.Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam +4 more
wiley +1 more source
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi +4 more
wiley +1 more source
, 2010 Mevalonate kinase deficiency (MKD) is a rare hereditary auto-inflammatory syndrome due to mutations in mevalonate kinase, the second enzyme of mevalonate pathway of cholesterol, and nonsterol-isoprenoids biosynthesis.
A. Pontillo +7 more
core +1 more source
A woman with recurrent "infections" since birth--a new mevalonate kinase mutation
, 2011 A tired 32-year-old woman complaining of tiredness was referred for work-up of a possible immune deficiency. She had a history of recurrent infections since birth, which usually responded to antibiotics within a few days.
Wanders, J. A. W. +3 more
core +2 more sources
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio +4 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang +3 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto +7 more
wiley +1 more source