Results 111 to 120 of about 13,572 (204)

Cross‐Species Reprogramming of Developmental Plasticity and Metabolic Rewiring via Banana‐Derived WUS2 Developmental Regulator

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4174-4189, June 2026.
ABSTRACT Plant regeneration is governed by intrinsic gene regulation and phytohormonal cues. WUSCHEL (WUS) gene promotes regeneration, but its broader functional role remains unexplored. Here, we demonstrate that the constitutive and inducible expression of banana‐derived WUS2 (GN‐WUS2) enhances regeneration in Nicotiana tabacum (tobacco) and Musa ...
Roni Chaudhary, Surender Singh, Usman Ali, Siddharth Tiwari   +3 more
wiley   +1 more source

Diagnostics and therapeutic insights in a severe case of mevalonate kinase deficiency

, 2007
Mevalonate kinase deficiency is a rare inborn disorder of isoprenoid and sterol biosynthesis characterized by a recurrent autoinflammatory syndrome and, in most severe cases, psychomotor delay.
Nevyjel, Marco, Waterham, Hans R., Barbi, Egidio, Pontillo, Alessandra, Tommasini, Alberto, Marilena Granzotto, Granzotto, Marilena, Alessandra Pontillo, Andrea D'Osualdo, Egidio Barbi, Lorenzo Calligaris, Alberto Tommasini, Sergio Crovella, D'Osualdo, Andrea, Alessandro Ventura, Calligaris, Lorenzo, Crovella, Sergio, Ventura, Alessandro, Marco Nevyjel, Hans R. Waterham   +19 more
core   +2 more sources

Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer

Frontiers in Pharmacology
IntroductionStatins, widely used for hypercholesterolemia, have shown anticancer properties including induction of apoptosis and ferroptosis, modulation of autophagy, and reprogramming of the tumor microenvironment, making them potential candidates for ...
Francisco Alejandro Lagunas-Rangel, Francisco Alejandro Lagunas-Rangel, Jörgen Jonsson, Ludmila Jackevica, Robert Fredriksson, Maija Dambrova, Maija Dambrova, Helgi B. Schiöth, Helgi B. Schiöth   +8 more
doaj   +1 more source

Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency. [PDF]

Glob Pediatr Health, 2023
Souali M, Sakhi A, Bousfiha AA, Bouayed K.   +3 more
europepmc   +1 more source

Case Report: Early-onset mevalonic aciduria in neonates with inflammatory marker elevated

Frontiers in Immunology
PurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory ...
Shanshan Xue, Shanshan Xue, Wujuan Shi, Wujuan Shi, Xiaobo He, Xiaobo He, Lihong Hao, Lihong Hao   +7 more
doaj   +1 more source

Respiratory deficiency in yeast mevalonate kinase deficient may explain MKD-associate metabolic disorder in humans

, 2018
Mevalonate kinase deficiency (MKD) an orphan drug rare disease affecting humans with different clinical presentations, is still lacking information about its pathogenesis; no animal or cell model mimicking the genetic defect, mutations at MVK gene, and ...
Paiva, Sérgio de Sá Leitão, Silva, Jaqueline Azevêdo, Morais Junior, Marcos Antonio de, Manuella Maria Silva Santos, Santos, Manuella Maria Silva, Souza, Rafael Barros de, Sérgio de Sá Leitão Paiva, Jaqueline Azevêdo Silva, Sergio Crovella, De Souza, Rafael Barros, Elsztein, Carolina, Carolina Elsztein, De Morais, Marcos Antonio, Crovella, Sergio, Rafael Barros De Souza, Marcos Antonio De Morais   +15 more
core   +1 more source

Two Siblings With Recurrent Fevers: The Path to Mevalonate Kinase Deficiency Diagnosis. [PDF]

Cureus, 2023
Pereira-Nunes J, Ferreras C, Grangeia A, Aguiar F, Rodrigues M, Brito I.   +5 more
europepmc   +1 more source

Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis

, 1999
Mevalonic aciduria is a rare autosomal recessive metabolic disorder, characterized by psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. The disorder is caused by a deficient activity of mevalonate kinase
Houten, S. M., Waterham, H. R., Duran, M., Romeijn, G. J., Waterham, HR, Duran, M, de Klerk, J. B., Smit, GPA, de Klerk, JBC, Gibson, KM, Koster, J, Gibson, K. M., Darbyshire, P, Gray, R. G. F., Wanders, RJA, Gray, RGF, Romeijn, GJ, Darbyshire, P., Smit, G. P., Gray, R. G., Houten, SM, Koster, J., Klerk, Hans, Wanders, R. J., Duran, M (Marinus)   +24 more
core   +1 more source

Mevalonate-Kinase Isoenzymes in Plant Cells [PDF]

Biochemical Journal, 1966
L J, Rogers, S P, Shah, T W, Goodwin
openaire   +2 more sources

Mevalonate kinase deficiency: enlarging the clinical and biochemical spectrum

, 2003
OBJECTIVE: Mevalonic aciduria as a result of mevalonate kinase deficiency is an inborn error of cholesterol biosynthesis characterized by dysmorphology, psychomotor retardation, progressive cerebellar ataxia, and recurrent febrile crises, usually ...
Zundel, Dorothee, Waterham, Hans R., Wanders, Ronald J. A., Dorothee Zundel, K. Michael Gibson, Ertan Mayatepek, Prietsch, Viola, Haas, Dorothea, Viola Prietsch, Hoffmann, Georg F., Dorothea Haas, Mayatepek, Ertan, Hermann Krastel, Gibson, K. Michael, Georg F. Hoffmann, Ronald J.A. Wanders, Krastel, Hermann, Hans R. Waterham   +17 more
core   +1 more source