Results 101 to 110 of about 13,572 (204)

Third Generation Genome Sequencing of the Endobacterium Corynebacterium kroppenstedtii subsp. demodicis Reveals Details of Its Microbe‐Host‐Interaction With the Most Complex Human Commensal, Demodex folliculorum

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
The symbiotic interaction between Demodex folliculorum and Corynebacterium kroppenstedtii subsp. demodicis. Created by the author based on genomic and functional analyses presented in this work. The tripartite interaction between the human host, the mite Demodex folliculorum, and its endosymbiont Corynebacterium kroppenstedtii subsp. demodicis.
T. Steegmüller, S. Walch, S. Gschwendtner, A. Klingl, L. E. French, M. Flaig, B. M. Clanner‐Engelshofen   +6 more
wiley   +1 more source

Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds.

, 1979
1. Mevalonate pyrophosphate decarboxylase of rat liver is inhibited by various phenyl and phenolic acids. 2. Some of the phenyl and phenolic acids also inhibited mevalonate phosphate kinase. 3.
Ramasarma, T, Bhat, Shama C
core  

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

The FEBS Journal, Volume 293, Issue 11, Page 3303-3319, June 2026.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa, Natsumi Matsushima, Soma Ishimine, Honoka Nakamoto, Hajime Hayakawa, Yoko Yasuno, Tetsuro Shinada, Hiroshi Kawaide, Tomokazu Ito, Hisashi Hemmi   +9 more
wiley   +1 more source

Discovery of a metabolic alternative to the classical mevalonate pathway

eLife, 2013
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas, Suzanne T Thomas, Gerard Manning, Joseph P Noel   +3 more
doaj   +1 more source

GPSM2 Promotes Pancreatic Cancer Progression Through METTL3‐Mediated m6A Modification of YAP1 mRNA

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Pancreatic cancer poses a major therapeutic challenge due to its insidious onset and difficulty in early diagnosis. G‐protein signalling modulator 2 (GPSM2), a member of the G‐protein signalling regulator family, is highly expressed in various tumour tissues; however, its role in pancreatic cancer remains largely undefined.
Jiajun Xiu, Li Qiao, Miaomiao Li, Xiaoan Hu, Zixuan Shen, Rui Yang, Hairu Zhang, Zhe Dong, Xuelei Liu, Yinghui Zhang   +9 more
wiley   +1 more source

Putative modifier genes in mevalonate kinase deficiency

, 2016
Mevalonate kinase deficiency (MKD) is an autosomal recessive auto‐inflammatory disease, caused by impairment of the mevalonate pathway. Although the molecular mechanism remains to be elucidated, there is clinical evidence suggesting that other regulatory
MARCUZZI, ANNALISA, VOZZI, DIEGO, TRICARICO, PAOLA MAURA, BIANCO, ANNA MONICA ROSARIA, Vuch Josef, Crovella Sergio, Tommasini Alberto, Knowles, Alessandra, PISCIANZ, ELISA, Vozzi Diego, GIRARDELLI, MARTINA, Bianco Anna Monica Rosaria, VUCH, JOSEF, Tricarico Paola Maura, Piscianz Elisa, Knowles Alessandra, Marcuzzi Annalisa, TOMMASINI, ALBERTO, CROVELLA, SERGIO, Girardelli Martina   +19 more
core   +1 more source

Repositioning Of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice [PDF]

, 2017
Mevalonate Kinase Deficiency (MKD, OMIM #610377) is a rare autosomal recessive metabolic and inflammatory disease. In MKD, defective function of the enzyme mevalonate kinase (MK), due to a mutation in the MVK gene, leads to the shortage of mevalonate ...
Kleiner, Giulio, Celeghini, Claudio, Marcuzzi, Annalisa, Loganes, Claudia   +3 more
core   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3597-3615, June 2026.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro, Alba López‐Laguna, Dolores Férnandez‐Ortuño, Alejandro Pérez‐García, Álvaro Polonio   +4 more
wiley   +1 more source

GRID2 a novel gene possibly associated with mevalonate kinase deficiency.

, 2015
Mevalonate kinase deficiency (MKD) is a rare autosomal disease caused by mutations in the mevalonate kinase gene (MVK). The genotype-phenotype correlation is sometimes problematic due to the great genetic and clinical heterogeneity; so we hypothesize ...
TRICARICO, PAOLA MAURA, Moura R, Campos Coelho AV, CROVELLA, SERGIO   +3 more
core   +1 more source