Results 121 to 130 of about 13,572 (204)

Characterization of a Feedback-Resistant Mevalonate Kinase from the Archaeon Methanosarcina mazei

open access: yes, 2011
The mevalonate pathway is utilized for the biosynthesis of isoprenoids in many bacterial, eukaryotic, and archaeal organisms. Based on previous reports of its feedback inhibition, mevalonate kinase (MVK) may play an important regulatory role in the ...
Mai Du   +6 more
core   +1 more source

The efficacy and safety of allogeneic stem cell transplantation in Mevalonate Kinase Deficiency. [PDF]

open access: yesPediatr Rheumatol Online J, 2022
Jeyaratnam J   +11 more
europepmc   +1 more source

Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

open access: yesCell Reports Medicine
Summary: The induction of immunogenic cell death (ICD) impedes tumor progression via both tumor cell-intrinsic and -extrinsic mechanisms, representing a robust therapeutic strategy.
Liming Gui   +5 more
doaj   +1 more source

Inhibition of mevalonate kinase by disulfide compounds

open access: yes, 1986
Mevalonate kinase (I) of rat liver could use ADP in place of ATP at low, nonsaturated concentrations of mevalonate. I was inhibited when both dithiothreitol (DTT) and $Fe^{2+}$ (or $Fe^{3+})$ were added, and this inhibitory effect was obtained in Tris ...
Ramasarma, T, Lalitha, R, Kalpana, GV
core  

Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani. [PDF]

open access: yesSci Rep, 2022
Prasad SR   +15 more
europepmc   +1 more source

Enzymatic Properties of Overexpressed HBV-Mevalonate Kinase Fusion Proteins and Mevalonate Kinase Proteins in the Human Hepatoma Cell Line PLC/PRF/5

open access: yes, 1995
We have previously reported a case of integration of HBV sequences in the 5′-noncoding region of the gene for mevalonate kinase (Mk) (EC.2.7.1.36) in the human hepatoma cell line PLC/PRF/5, resulting in overexpression of viral-cellular fusion transcripts
Koshy, R.   +3 more
core   +1 more source

An Atypical Presentation of Mevalonate Kinase Deficiency in Response to Colchicine Treatment. [PDF]

open access: yesMol Syndromol, 2022
Koç Yekedüz M   +5 more
europepmc   +1 more source

Cutaneous manifestations in mevalonate kinase deficient patients treated with canakinumab

open access: yes, 2020
Canakinumab is a human monoclonal antibody anti-interleukin-1β, it is the only biologic drug approved to treat mevalonate kinase deficiency (MKD). Canakinumab injection can trigger several local cutaneous reactions, but also chronic-relapsing skin ...
Conte, Mariasole   +4 more
core  

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