Results 211 to 220 of about 38,617 (240)
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Both the mevalonate and the non-mevalonate pathways are involved in ginsenoside biosynthesis
Plant Cell Reports, 2013When one of them was inhibited, the two pathways could compensate with each other to guarantee normal growth. Moreover, the sterol biosynthesis inhibitor miconazole could enhance ginsenoside level.Ginsenosides, a kind of triterpenoid saponins derived from isopentenyl pyrophosphate (IPP), represent the main pharmacologically active constituents of ...
Shoujing, Zhao +5 more
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Cardioprotection by Farnesol: Role of the Mevalonate Pathway
Cardiovascular Drugs and Therapy, 2013Farnesol is a key metabolite of the mevalonate pathway and known as an antioxidant. We examined whether farnesol treatment protects the ischemic heart.Male Wistar rats were treated orally with 0.2, 1, 5, and 50 mg/kg/day farnesol/vehicle for 12 days, respectively. On day 13, the effect of farnesol treatment on cardiac ischemic tolerance and biochemical
Szűcs, Gergő +8 more
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Biosynthesis of isoprenoids via the non-mevalonate pathway
Cellular and Molecular Life Sciences, 2004The mevalonate pathway for the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), is known in considerable detail. Only recently, the existence of a second mevalonate-independent pathway for the biosynthesis of IPP and DMAPP was detected in plants and certain eubacteria.
W, Eisenreich +3 more
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Targeting the Mevalonate Pathway for Treating Lung Cancer
American Journal of Clinical Oncology, 2019The mevalonate (MVA) pathway is a key metabolic pathway involved in various important cellular functions. Its downstream products are critical for cell-signaling, cell membrane integrity, protein synthesis, and cellular respiration. The rate-limiting enzyme of this pathway is targeted by statins, a class of medications best known for their lipid ...
Ali, Fatehi Hassanabad, Fady, Mina
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Metabolic Engineering of the Mevalonate and Non-Mevalonate Pathways in Tomato
2003In higher plants isoprenoids have many essential roles e.g. in membrane structure (phytosterols), redox chemistry (plastoquinone) and as antioxidants (carotenoids). Despite their functional and chemical diversity all isoprenoids are biosynthetically related from a common precursor, isopentenyl pyrophosphate (IPP).
E. M. Enfissi +5 more
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Distribution, Biosynthesis, and Function of Mevalonate Pathway Lipids
1993The structures and biosynthesis of mevalonate pathway lipids, and in particular of cholesterol, have been intensively investigated throughout most of this century and a large amount of data have accumulated. In spite of this enormous effort, completely new information concerning the membrane organization, compartmentalization, function, and metabolic ...
J, Ericsson, G, Dallner
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Targeting the Mevalonate Pathway for Improved Anticancer Therapy
Current Cancer Drug Targets, 2009The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho)
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Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy
Current Cancer Drug TargetsAbstract: Tumors of the digestive system are currently one of the leading causes of cancer-related death worldwide. Despite considerable progress in tumor immunotherapy, the prognosis for most patients remains poor. In the tumor microenvironment (TME), tumor cells attain immune escape through immune editing and acquire immune tolerance. The mevalonate
Zongrui Xing +3 more
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