Results 131 to 140 of about 5,897 (180)
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Journal of Chromatography B, Biomedical Sciences and Applications, 2001
Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis.
B H, Woollen +3 more
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Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis.
B H, Woollen +3 more
exaly +3 more sources
Biochimica et Biophysica Acta, 1962
Abstract The requirement of three species of lactobacillus for acetate and its replacement by mevalonic acid was investigated. It was found that, in the presence of 1% glucose, Lactobacillus acidophilus had a requirement for sodium acetate which could be replaced by 1/8000 times its concentration of mevalonic acid, but when the glucose ...
K J, THORNE, E, KODICEK
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Abstract The requirement of three species of lactobacillus for acetate and its replacement by mevalonic acid was investigated. It was found that, in the presence of 1% glucose, Lactobacillus acidophilus had a requirement for sodium acetate which could be replaced by 1/8000 times its concentration of mevalonic acid, but when the glucose ...
K J, THORNE, E, KODICEK
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Occurrence of Mevalonic Acid in Carrots
Nature, 1961ALTHOUGH tracer studies in a number of carotenogenic systems1,2 have conclusively proved that mevalonic acid is an effective precursor of carotenes, the presence of mevalonic acid has not been demonstrated in any of such systems. In this laboratory an attempt has been made to isolate mevalonic acid from carrots.
V V, MODI, D K, PATWA
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In Vitro Metabolism of Mevalonic Acid in the Bovine Retina
Journal of Neurochemistry, 1986Abstract: Bovine retinas were incubated with 3RS‐[5‐3H]‐ mevalonic acid under conditions similar to those previously shown to support opsin biosynthesis in vitro. TLC of the total lipids indicated the formation of numerous radiolabeled components, including sterols, hydrocarbons, and “fatty acid‐like material.” The nonsaponifiable lipids were analyzed
Steven J Fliesler +2 more
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Is mevalonic acid a precursor of the corticosteroids?
Archives of Biochemistry and Biophysics, 1962Abstract Bovine adrenal tissue preparations (whole homogenates or a combination of microsomal and supernatant fractions) readily convert acetate-1-C 14 to corticosteroids, 14 of which have been isolated and identified. In parallel experiments with aliquots of the same adrenal tissue preparations, mevalonate-2-C 14 was not found to be incorporated ...
M J, BRYSON, M L, SWEAT
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Metabolism of mevalonic acid to phosphorylated derivatives in Chlorella
Biochemical and Biophysical Research Communications, 1977Summary The incorporation of mevalonic acid into phosphorylated derivatives was studied for the first time in Chlorophyceae algae. Cell-free extracts and cell suspensions of Chlorella fusca were able to phosphorylate mevalonic acid. The total mevalonate phosphorylation showed a clear maximum at pH 8.2.
A, Linares +2 more
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Mevalonic Acid Analogs as Inhibitors of Cholesterol Biosynthesis
Journal of Pharmaceutical Sciences, 1981A series of 20 mevalonic acid analogs was synthesized and tested for their ability to inhibit cholesterol biosynthesis from [2-14C]-mevalonate in rat liver homogenates. Removal of the 5-hydroxyl group from mevalonic acid produced an active inhibitor, 3-hydroxy-3-methylpentanoic acid. Removal of the 3-hydroxyl group, addition of an aromatic group in the
C R, DeBold, J C, Elwood
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Biochimica et Biophysica Acta, 1962
Abstract In an investigation of the synthesis of the unsaponifiable lipids of Lactobacillus casei from mevalonic acid, it was shown that although no preferential order of synthesis of the components could be detected there was a turnover of the principal one with a simultaneous increase in the others.
K J, THORNE, E, KODICEK
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Abstract In an investigation of the synthesis of the unsaponifiable lipids of Lactobacillus casei from mevalonic acid, it was shown that although no preferential order of synthesis of the components could be detected there was a turnover of the principal one with a simultaneous increase in the others.
K J, THORNE, E, KODICEK
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Comparative Biosynthesis of Mevalonic Acid by Mycoplasma
Journal of Bacteriology, 1965Smith, Paul F. (University of South Dakota, Vermillion), and C. V. Henrikson . Comparative biosynthesis of mevalonic acid by Mycoplasma . J. Bacteriol. 89: 146–153. 1965.—Three representative Mycoplasma, M. laidlawii strain B,
P F, SMITH, C V, HENRIKSON
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An improved chemical ionization assay for mevalonic acid
Biological Mass Spectrometry, 1990The determination of mevalonic acid by gas chromatography/mass spectrometry (GC/MS) is complicated by poor extractability and multiple product formation. Reliable quantification down to physiological levels was achieved by isolating mevalonic acid by liquid partition chromatography and quantifying the underivatized lactone by means of ammonia chemical ...
G F, Hoffmann, L, Sweetman
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