Results 131 to 140 of about 249 (164)

[Electrophysiological study of the mechanism of mexidol action].

Eksperimental'naia i klinicheskaia farmakologiia, 2012
It has been found that mexidol (5 mM) significantly (96 +/- 2%) depressed excitatory postsynaptic current caused by step depolarization in neurons of medial vestibular nucleus of medulla oblongata slices in young (aged 13 - 17 days) male albino rats.
V G, Motin, V V, Iasnetsov, A A, Zabozlaev, S K, Karsanova, V V, Iasnetsov   +4 more
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[Antihypoxic and antiamnesic effects of mexidol and semax].

Eksperimental'naia i klinicheskaia farmakologiia, 2010
Upon single administration, mexidol and semax only in doses of 100 and 0.05 mg/kg, respectively, produced an antihypoxic effect on mice in the altitude chamber and hermetic chamber tests. Preventive course administration of mexidol and semax for 6 days gave significant antihypoxic effect on the model of acute hypobaric hypoxia in mice in doses of 75 ...
Vik V, Iasnetsov, T A, Voronina
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[On the mechanism of antimotion sickness effects of mexidol].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 2011
The path-clamp method used within the whole-cell configuration in experiments with convoluted medullar oblongata sections obtained from white mongrel male rats aged 13 to 17 days evidenced that 5 mV of mexidol caused 96 +/- 2% inhibition of the excitation postsynaptic current in neurons of the medial vestibular nucleus generated by the depolarization ...
V G, Motin, V V, Iasnetsov
openaire   +1 more source

[Efficiency of mexidol in patients with endocrine polyneuropathy].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014
To evaluate the efficacy of mexidol and necessity of using it in patients with endocrine polyneuropathies caused by primary hypothyroidism (PPHT). MATERIALS AND METHODS; We have examined 51 patients with confirmed diagnosis of PPHT and assessed their neurological status and indicators of metabolic homeostasis before and after treatment ...
E B, Kuznetsova, I I, Sholomov, S V, Gerasimov, E A, Salina   +3 more
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New aspects of the energy-tropic action of mexidol

ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 2018
Митохондриогенез и ангиогенез являются ключевыми нейропротекторными механизмами, повышающими устойчивость нервной ткани к условиям гипоксии/ишемии. В настоящее время фармакологическая индукция биогенеза митохондрий является одним из наиболее перспективных и активно разрабатываемых подходов к коррекции ишемических и постишемических нарушений ...
openaire   +1 more source

[Effects of vestibuloprotectors mexidol and melatonin on animal cerebellum].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 2015
In experiments with cats, air-assisted microinjections of mexidol and melatonin had a direct effect on 71-81% Purkinje cells inducing the inhibitory response 4.2-6.3 times more often than exiting. In case of concurrent action of MK-801 (a specific noncompetitive NMDA-receptor antagonist) the mexidol effect on the spontaneous activity was suppressed ...
V V, Iasnetsov, V G, Motin, V V, Jasnecov, S K, Karsanova, Ju V, Ivanov, N A, Chel'naja   +5 more
openaire   +1 more source

[Effect of mexidol on the course of post-traumatic epilepsy].

Eksperimental'naia i klinicheskaia farmakologiia, 2003
The results of a complex 10-day therapy of patients with posttraumatic epilepsy, involving the antioxidant mexidol, are presented. The efficacy of the therapy was assessed based on the data of clinico-neurological, instrumental, and immunological examinations before and after the treatment and evaluated in terms of the dynamics of the neurological ...
V E, Novikov, N N, Maslova
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[The use of mexidol in urgent treatment of drug addiction].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007
Results of the clinical study of efficacy and tolerability of mexidol administered in intravenous drop-by-drop introduction during 5-7 days in the therapy of 50 cases of complicated alcoholic delirium are presented. The patient condition and changes in device test data were assessed in comparison with those of a control group of patients receiving a ...
O I, Klindukhova, O E, Novgorodov, N N, Sergienko, P V, Daniliuk, O V, Belotserkovich   +4 more
openaire   +1 more source

The possibilities of Mexidol in the complex therapy of arterial hypertension

Russian Journal of Cardiology and Cardiovascular Surgery
A review of the literature is devoted to the effects of the ethylmethylhydroxypyridine succinate (mexidol) in patients with arterial hypertension. The analysis of 44 sources of Russian and foreign literature showed more effective achievement of the target values of blood pressure, prevention of severe complications in hypertensive crises in patients ...
V.P. Mikhin, N.L. Kostina, T.A. Nikolenko, V.V. Savelyeva, M.A. Chernyatina   +4 more
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[Acute radiation sickness in experiment. Efficacy of mexidol].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2007
Experiments on mice were made to examine mexidol effects on the course and outcome of acute radiation sickness (ARS). Regenerative processes in hemopoietic system were studied after 6.0 Gy radiation, survival of the animals was studied in 7.7 Gy radiation. Mexidol was used in two schemes. Scheme one--once a day on days 1-8 after radiation.
Iu B, Deshevoĭ, B B, Moroz, G V, Cukoian, T A, Voronina, V G, Lebedev, A V, Lyrshchikova   +5 more
openaire   +1 more source