Results 111 to 120 of about 249 (164)
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Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol
Bulletin of Experimental Biology and Medicine, 2023The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight. The concentration of succinate in blood plasma, cytoplasmic and mitochondrial fractions of cells of the cerebral cortex, left-ventricular myocardium, and liver was measured by HPLC-MS/MS.
A V, Shchulkin +4 more
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019
To study the efficacy and safety of Mexidol used intravenously (500 mg 1 time per day) for 14 days, followed by the oral administration of Mexidol Forte 250 in a dose of 250 mg 3 times a day for 60 days, in patients with chronic cerebral ischemia (CCI).The study included 56 patients with CCI due to a combination of hypertension and atherosclerosis. The
V A, Kutashov, O V, Ulyanova
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To study the efficacy and safety of Mexidol used intravenously (500 mg 1 time per day) for 14 days, followed by the oral administration of Mexidol Forte 250 in a dose of 250 mg 3 times a day for 60 days, in patients with chronic cerebral ischemia (CCI).The study included 56 patients with CCI due to a combination of hypertension and atherosclerosis. The
V A, Kutashov, O V, Ulyanova
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Lymphotropic Effect of Mexidol in Reactive Fever
Bulletin of Experimental Biology and Medicine, 2005Single injection of mexidol (drug with antioxidant and membranotropic effects) to animals with reactive fever produces a multicomponent effect on the lymph circulation. The drug increased the number of functioning lymph capillaries and contractile activity of wall and valvular leaflets in rat small intestinal mesenteric lymphangion, accelerated lymph ...
R K, Khafiz'yanova, D A, Mukhutdinov
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Combined administration of mexidol with known medicines
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019This review summarizes the available data on the combined administration of mexidol with medicines of different pharmacotherapeutic groups. Mexidol has a multifaceted mechanism of action and exhibits a wide range of pharmacological effects. It enhances therapeutic effects of a variety of drugs in research and clinical settings, boosts the effectiveness
T A, Voronina, E A, Ivanova
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2020
To study the efficacy and safety of mexidol's intravenous injections (500 mg once a day) for 14 days, followed by oral administration of mexidol FORTE 250 at a dose of 250 mg (1 tablet) 3 times a day for 60 days, in treatment of chronic cerebral ischemia (CCI) in patients with hypertension and atherosclerosis of the brachiocephalic arteries.The ...
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To study the efficacy and safety of mexidol's intravenous injections (500 mg once a day) for 14 days, followed by oral administration of mexidol FORTE 250 at a dose of 250 mg (1 tablet) 3 times a day for 60 days, in treatment of chronic cerebral ischemia (CCI) in patients with hypertension and atherosclerosis of the brachiocephalic arteries.The ...
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A comparative study of mexidol and mexiprim pharmacokinetic parameters
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2014Objective. To compare pharmacokinetic parameters of mexidol (coated tablets, "Farmasoft") and mexiprim (tablets film-coated, "STADA CIS"). Material and methods. The study included 14 adult male Chinchilla rabbits. Concentration of 2-ethyl-6-methyl-3-hydroxypyridine succinate in the blood plasma of animals was analyzed using HPLC with UV detection ...
A V, Shchul'kin +2 more
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Mexidol in the rehabilitation of patients in the acute ischemic stroke
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2015Research objective - studying of results of a comprehensive neuro-rehabilitation patients in the acute ischemic stroke (according to the Samara regional vascular centre).A review of the work of RVC on the main indicators for 2014, detailed analysis of 20 patients in the acute period of ischemic stroke, in which treatment was used the drug mexidol with ...
O V, Androfagina +2 more
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Possibilities of using Mexidol in the complex therapy of mental disorders
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2020A review of the current literature on the possible use of mexidol (ethylmethylhydroxypyridine succinate) in the treatment of mental (including addictive) disorders is conducted. The possibility of its use to reduce negative psychopathological symptoms, neurocognitive deficit, manifestations of the antipsychotic syndrome (including its extrapyramidal ...
V K, Shamrey +4 more
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Mnemotropic and anxiolytic activity of mexidol and enoxifol
Journal of New Medical Technologies. eJournal, 2015The article presents the research findings of influence of antioxidant compounds Enoxifol (10 mg/kg) and Mexidol (100 mg/kg) on behavior, emotional sphere and ability for self-regulation of experimental animals. The mechanism of Enoxifol and Mexidol action at high nervous functions was established on the basis of tests allowing to ...
I. Tregubova, null Трегубова
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A modern concept of antihypoxic and antioxidant effects of mexidol
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018The review article presents a modern concept of the mechanism of antioxidant and antihypoxic action of the original drug mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate). The direct antioxidant activity of mexidol has been described, which consists in the ability of the drug to inactivate free radicals and increase the activity of the antioxidant
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