Results 101 to 110 of about 562 (137)

[GABAergic mechanism of cerebrovasculareffect of mexidol].

Eksperimental'naia i klinicheskaia farmakologiia, 2011
Experiments on rats showed that mexidol significantly increases local cerebral blood flow in animals under conditions of global transient brain ischemia, whereas in intact rats this drug initially causes a decrease in the blood flow, followed by its recovery.
A V, gnezdilova, T S, Gan'shina, R S, Mirzoian   +2 more
openaire   +1 more source

[Effectiveness of mexidol in acute pancreatitis].

Klinicheskaia meditsina, 2002
Mexidol effectiveness was tried in acute pancreatitis (AP). It was found that in acute pancreatitis mexidol provides a reliable defence of membrane structures, decreased the rate of lipid peroxidation, enhanced the activity of the antioxidative system. This eventually results in reduced number of AP complications (by 9-13%) and mortality (by 7%). In AP
Iu V, Ivanov, S M, Chudnykh, A G, Mozgalin   +2 more
openaire   +1 more source

[Gastroprotective properties of mexidol and hypoxen].

Eksperimental'naia i klinicheskaia farmakologiia, 2010
Experimental damage in the stomach mucosa of test rats was modeled by acetylsalicylic acid (aspirin-induced ulcerogenesis). The number of ulcers and the total area of erosive injury in the mucous membrane were studied. Prophylactic treatment with mexidol and hypoxen in a daily dose of 50 mg/kg reduces the aspirin-induced damage of stomach mucosa.
V E, Novikov, N O, Kriukova, A S, Novikov   +2 more
openaire   +1 more source

[The use of mexidol in psychiatric practice].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2006
Mexidol has been used in combination with basic therapy in 65 patients with mental disorders of organic genesis. The patients were treated during 56 days in accordance with a special scheme including the drug intake and intramuscular and intravenous injections.
V G, Kosenko, E A, Karagezian, L V, Luneva, L F, Smolenko   +3 more
openaire   +1 more source

The mexidol effects for activation of mitochondrial activity in athletes

Journal of New Medical Technologies. eJournal, 2015
This brief report presents a description of the basic properties of mitochondria, providing a formation of energy in the human body, the ability to control a formation of energy under the influence of the Mexidol. The authors showed the main physiological effects of Mexidol in athletes and in various pathologies.
A. Nesmeyanov, null Несмеянов, Aleksandr Khadartsev, null Хадарцев, N. Fudin, null Фудин   +5 more
openaire   +1 more source

[Cerebrovascular and antiserotoninergic activity of the combination of tropoxin and mexidol].

Eksperimental'naia i klinicheskaia farmakologiia, 2012
The results of experiments on narcotized rats showed that tropoxin substantially reduces the constrictor reactions of cerebral blood vessels to meta-chlorophenylpiperazine, while not increasing the blood flow in the carotid system of either intact rats or animals with model ischemic damage of brain.
A A, Gorbunov, T S, Gan'shina, A I, Turilova, R S, Mirzoian   +3 more
openaire   +2 more sources

Evaluation of the neuroprotective activity of Mexidol in a model of hemorrhagic stroke

S.S. Korsakov Journal of Neurology and Psychiatry
Objective. To comprehensively evaluate the neuroprotective potential of Mexidol following systemic administration in various dosage forms in a model of hemorrhagic stroke. Material and methods. The study was performed on 130 outbred male rats, weighing 180—200 g and aged 7—8 weeks.
A.V. Shchulkin, I.V. Chernykh, S.K. Pravkin, Yu.V. Abalenikhina   +3 more
openaire   +2 more sources

[Electrophysiological study of the mechanism of mexidol action].

Eksperimental'naia i klinicheskaia farmakologiia, 2012
It has been found that mexidol (5 mM) significantly (96 +/- 2%) depressed excitatory postsynaptic current caused by step depolarization in neurons of medial vestibular nucleus of medulla oblongata slices in young (aged 13 - 17 days) male albino rats.
V G, Motin, V V, Iasnetsov, A A, Zabozlaev, S K, Karsanova, V V, Iasnetsov   +4 more
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[Antihypoxic and antiamnesic effects of mexidol and semax].

Eksperimental'naia i klinicheskaia farmakologiia, 2010
Upon single administration, mexidol and semax only in doses of 100 and 0.05 mg/kg, respectively, produced an antihypoxic effect on mice in the altitude chamber and hermetic chamber tests. Preventive course administration of mexidol and semax for 6 days gave significant antihypoxic effect on the model of acute hypobaric hypoxia in mice in doses of 75 ...
Vik V, Iasnetsov, T A, Voronina
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[On the mechanism of antimotion sickness effects of mexidol].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine, 2011
The path-clamp method used within the whole-cell configuration in experiments with convoluted medullar oblongata sections obtained from white mongrel male rats aged 13 to 17 days evidenced that 5 mV of mexidol caused 96 +/- 2% inhibition of the excitation postsynaptic current in neurons of the medial vestibular nucleus generated by the depolarization ...
V G, Motin, V V, Iasnetsov
openaire   +1 more source