Results 81 to 90 of about 562 (137)
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Quantitative Analysis of the Antioxidant Activity of Mexidol
Pharmaceutical Chemistry Journal, 2021The antioxidant activity of the drug Mexidol was quantitatively measured using an objective method. The rate constant for the reaction of Mexidol with peroxyl radicals of 1,4-dioxane was measured in 1,4-dioxane solution. Mexidol was found to inhibit oxidation of 1,4-dioxane and showed good antioxidant activity comparable to that of ionol.
Rustam L Safiullin +2 more
exaly +2 more sources
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2022
To evaluate the effect of Mexidol on the recovery of cognitive functions in patients after ischemic stroke (IS).We examined 70 patients with acute IS, who were randomized into 2 groups by random sampling; The 1st group consisted of patients who, against the background of the main standard therapy for 14 days, received Mexidol intravenously, 500 mg 1 ...
S.M. Karpov +4 more
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To evaluate the effect of Mexidol on the recovery of cognitive functions in patients after ischemic stroke (IS).We examined 70 patients with acute IS, who were randomized into 2 groups by random sampling; The 1st group consisted of patients who, against the background of the main standard therapy for 14 days, received Mexidol intravenously, 500 mg 1 ...
S.M. Karpov +4 more
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Antihypoxic and Antinecrotic Effect of Mexidol in Skin Ischemia
Bulletin of Experimental Biology and Medicine, 2005Course treatment with mexidol in a dose of 25 mg/kg for 3 days decreased activities of aspartate transaminase and creatine phosphokinase in the plasma on day 3 after the incidence of skin ischemia (by 1.3 and 1.66 times, respectively). Under these conditions the index of cytolysis decreased by 1.3 times.
Vasily A Popkov +2 more
exaly +3 more sources
Experience with mexidol in neurological practice
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018Antihypoxic, antioxidant and nootropic effects of mexidol contribute to the improvement of patients with cerebrovascular pathology. The results of clinical studies show that the sequential scheme of using mexidol (first i.v. or i.m., then per os) is effective in the complex therapy of ischemic diseases of the brain, vascular surgery, therapy and ...
O A, Gromova +5 more
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A comparative chemoreactome analysis of mexidol
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2017To compare mexidol with control molecules (choline alfoscerate, piracetam, glycine, semax) using chemoreactome analysis.The chemical structure of mexidol was compared to molecule metabolites extracted from the Human Metabolome Database (HMDB) and a drug database.
I Yu, Torshin +3 more
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Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol
Bulletin of Experimental Biology and Medicine, 2023The pharmacokinetics of succinate was studied in Wistar rats after a single intravenous administration of Mexidol in a dose 100 mg/kg body weight. The concentration of succinate in blood plasma, cytoplasmic and mitochondrial fractions of cells of the cerebral cortex, left-ventricular myocardium, and liver was measured by HPLC-MS/MS.
A V, Shchulkin +4 more
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019
To study the efficacy and safety of Mexidol used intravenously (500 mg 1 time per day) for 14 days, followed by the oral administration of Mexidol Forte 250 in a dose of 250 mg 3 times a day for 60 days, in patients with chronic cerebral ischemia (CCI).The study included 56 patients with CCI due to a combination of hypertension and atherosclerosis. The
V A, Kutashov, O V, Ulyanova
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To study the efficacy and safety of Mexidol used intravenously (500 mg 1 time per day) for 14 days, followed by the oral administration of Mexidol Forte 250 in a dose of 250 mg 3 times a day for 60 days, in patients with chronic cerebral ischemia (CCI).The study included 56 patients with CCI due to a combination of hypertension and atherosclerosis. The
V A, Kutashov, O V, Ulyanova
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Lymphotropic Effect of Mexidol in Reactive Fever
Bulletin of Experimental Biology and Medicine, 2005Single injection of mexidol (drug with antioxidant and membranotropic effects) to animals with reactive fever produces a multicomponent effect on the lymph circulation. The drug increased the number of functioning lymph capillaries and contractile activity of wall and valvular leaflets in rat small intestinal mesenteric lymphangion, accelerated lymph ...
R K, Khafiz'yanova, D A, Mukhutdinov
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Combined administration of mexidol with known medicines
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019This review summarizes the available data on the combined administration of mexidol with medicines of different pharmacotherapeutic groups. Mexidol has a multifaceted mechanism of action and exhibits a wide range of pharmacological effects. It enhances therapeutic effects of a variety of drugs in research and clinical settings, boosts the effectiveness
T A, Voronina, E A, Ivanova
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Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2020
To study the efficacy and safety of mexidol's intravenous injections (500 mg once a day) for 14 days, followed by oral administration of mexidol FORTE 250 at a dose of 250 mg (1 tablet) 3 times a day for 60 days, in treatment of chronic cerebral ischemia (CCI) in patients with hypertension and atherosclerosis of the brachiocephalic arteries.The ...
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To study the efficacy and safety of mexidol's intravenous injections (500 mg once a day) for 14 days, followed by oral administration of mexidol FORTE 250 at a dose of 250 mg (1 tablet) 3 times a day for 60 days, in treatment of chronic cerebral ischemia (CCI) in patients with hypertension and atherosclerosis of the brachiocephalic arteries.The ...
openaire +2 more sources