Results 31 to 40 of about 5,281 (192)

Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity

Vaccines, 2021
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of ...
Zhuofan Li, Yiwen Zhao, Yibo Li, Xinyuan Chen   +3 more
doaj   +1 more source

Poloxamer-188 Adjuvant Efficiently Maintains Adaptive Immunity of SARS-CoV-2 RBD Subunit Vaccination through Repressing p38MAPK Signaling

Vaccines, 2022
Poloxamer-188 (P188) is a nonionic triblock linear copolymer that can be used as a pharmaceutical excipient because of its amphiphilic nature. This study investigated whether P188 can act as an adjuvant to improve the immunogenicity of severe acute ...
Chao-Hung Chen, Yu-Jen Lin, Li-Ting Cheng, Chien-Hung Lin, Guan-Ming Ke   +4 more
doaj   +1 more source

Sicurezza e tollerabilità dei vaccini adiuvati con MF59

, 2010
Vengono descritte le caratteristiche di efficacia e di sicurezza del vaccino adiuvato con mf59 dopo oltre 10 anni di ...
F. Pregliasco
core   +2 more sources

Cost-effectiveness analysis of different seasonal influenza vaccines in the elderly Italian population

Human Vaccines & Immunotherapeutics, 2018
In the perspective of reaching at least 75% influenza vaccination coverage in the elderly and substantial budget constraints, Italian decision makers are facing important challenges in determining an optimal immunization strategy for this growing and ...
Stefano Capri, Marco Barbieri, Chiara de Waure, Sara Boccalini, Donatella Panatto   +4 more
doaj   +1 more source

Evaluating the Immune Response of Recombinant H1N1 Hemagglutinin with MF59 Adjuvant in Animal Model as a Novel Alternative to the Influenza Vaccine

Iranian Journal of Allergy, Asthma and Immunology, 2020
The H1N1 influenza virus is known as a serious pandemic threat across the globe. Vaccination is one of the most effective methods of protection against this virus and the way to reduce the seasonal pandemic risk.
Niloufar Rashedi, Morteza Taghizadeh, Parisa Mohamadynejad, Mehdi Mahdavi, Reza Jalalirad   +4 more
doaj   +1 more source

Melatonin as Immune Potentiator for Enhancing Subunit Vaccine Efficacy against Bovine Viral Diarrhea Virus

Vaccines, 2021
Bovine viral diarrhea virus (BVDV) is a pathogen associated with substantial economic losses in the dairy cattle industry. Currently, there are no effective vaccines against BVDV.
Yi-Xuan Wang, Guang-Hui Yang, Lin-Lin Zhang, Jing Wang, Jiu-Feng Wang   +4 more
doaj   +1 more source

Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice

Frontiers in Immunology, 2019
Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited due to poorly developed follicular dendritic cells (FDC), causing generation of few antibody-secreting cells (ASCs) with ...
Audur Anna Aradottir Pind, Audur Anna Aradottir Pind, Magdalena Dubik, Magdalena Dubik, Sigrun Thorsdottir, Andreas Meinke, Ali M. Harandi, Ali M. Harandi, Jan Holmgren, Jan Holmgren, Giuseppe Del Giudice, Ingileif Jonsdottir, Ingileif Jonsdottir, Ingileif Jonsdottir, Stefania P. Bjarnarson, Stefania P. Bjarnarson   +15 more
doaj   +1 more source

Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. [PDF]

PLoS ONE, 2013
Pregnant women were suspected to be at particular risk when H1N1pnd09 influenza became pandemic in 2009. Our primary objective was to compare the immune responses conferred by MF59®-adjuvanted vaccine (Focetria®) in H1N1pnd09-naïve pregnant and non ...
Anne Louise Bischoff, Nilofar Vahman Følsgaard, Charlotte Giwercman Carson, Jakob Stokholm, Louise Pedersen, Maria Holmberg, Amalie Bisgaard, Sune Birch, Theodore F Tsai, Hans Bisgaard   +9 more
doaj   +1 more source

Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120–MF59 in Adults

New England Journal of Medicine, 2021
A safe, effective vaccine is essential to eradicating human immunodeficiency virus (HIV) infection. A canarypox-protein HIV vaccine regimen (ALVAC-HIV plus AIDSVAX B/E) showed modest efficacy in reducing infection in Thailand. An analogous regimen using HIV-1 subtype C virus showed potent humoral and cellular responses in a phase 1-2a trial in South ...
Glenda E. Gray, Linda-Gail Bekker, Fatima Laher, Mookho Malahleha, Mary Allen, Zoe Moodie, Nicole Grunenberg, Yunda Huang, Doug Grove, Brittany Prigmore, Jia J. Kee, David Benkeser, John Hural, Craig Innes, Erica Lazarus, Graeme Meintjes, Nivashnee Naicker, Dishiki Kalonji, Maphoshane Nchabeleng, Modulakgotla Sebe, Nishanta Singh, Philip Kotze, Sheetal Kassim, Thozama Dubula, Vimla Naicker, William Brumskine, Cleon N. Ncayiya, Amy M. Ward, Nigel Garrett, Girisha Kistnasami, Zakir Gaffoor, Pearl Selepe, Philisiwe B. Makhoba, Matsontso P. Mathebula, Pamela Mda, Tania Adonis, Katlego S. Mapetla, Bontle Modibedi, Tricia Philip, Gladys Kobane, Carter Bentley, Shelly Ramirez, Simbarashe Takuva, Megan Jones, Mpho Sikhosana, Millicent Atujuna, Michele Andrasik, Nima S. Hejazi, Adrian Puren, Lubbe Wiesner, Sanjay Phogat, Carlos Diaz Granados, Marguerite Koutsoukos, Olivier Van Der Meeren, Susan W. Barnett, Niranjan Kanesa-Thasan, James G. Kublin, M. Juliana McElrath, Peter B. Gilbert, Holly Janes, Lawrence Corey   +60 more
openaire   +3 more sources

Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants.

PLoS ONE, 2012
Adjuvant formulations capable of inducing high titer and high affinity antibody responses would provide a major advance in the development of vaccines to viral infections such as HIV-1. Although oil-in-water emulsions, such as Freund's adjuvant (FCA/FIA),
Rachel P J Lai, Michael S Seaman, Paul Tonks, Frank Wegmann, David J Seilly, Simon D W Frost, Celia C LaBranche, David C Montefiori, Antu K Dey, Indresh K Srivastava, Quentin Sattentau, Susan W Barnett, Jonathan L Heeney   +12 more
doaj   +1 more source