Results 41 to 50 of about 5,281 (192)
MF59™-adjuvanted seasonal influenza vaccine in young children
Influenza is a viral disease of the upper respiratory tract, which is manifested in seasonal epidemic waves associated with excess morbidity and mortality. Although efforts at prevention have traditionally been focused on the elderly, interest is growing on the specific features of influenza disease in children and the opportunities for prevention in ...
Puig-Barbera J +2 more
openaire +3 more sources
Development of MF-59 adjuvant using chitosan derivatives to influenza vaccine [PDF]
Background & Objective: The influenza virus causes hundreds of deaths in the world. Despite the availability of some authorized vaccines for all age groups and its approved beneficial effects, the influenza is still a major problem for public health ...
Alireza Loghmani +2 more
doaj
The ALVAC-HIV clade B/AE and equivalent SIV-based/gp120 + Alum vaccines successfully decreased the risk of virus acquisition in humans and macaques. Here, we tested the efficacy of HIV clade B/C ALVAC/gp120 vaccine candidates + MF59 or different doses of
Luca Schifanella +27 more
doaj +1 more source
Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani +2 more
wiley +1 more source
Serum neutralizing activity against SHIV-C challenge stocks in animals immunized in Study 3 (MF59).
Serum neutralizing activity against SHIV-C challenge stocks in animals immunized in Study 3 (MF59).
Melvin N. Doster (6694943) +26 more
core +1 more source
ABSTRACT Preexisting immunity to influenza confers rapid protection against antigenically matched viruses but can also constrain responses to drifted variants. This review asks when and why prior infection or vaccination is protective versus detrimental, and which biological mechanisms—epitope masking by circulating antibody, inhibitory FcγRIIb ...
Annette Fox +2 more
wiley +1 more source
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus can reduce efficacy and so influenza remains a major threat to public health.
John S. Tregoning +2 more
doaj +1 more source
A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis [PDF]
Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation ...
Tamara Aghebati +9 more
doaj +1 more source
Summary: Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during ...
Georgia Deliyannis +40 more
doaj +1 more source
Graphical Abstract and Lay Summary Nanoemulsions are promising vaccine adjuvants and drug delivery vehicles. In this work, we have demonstrated that sterile filtration performance can be significantly enhanced by prewetting the sterile filter with Polysorbate 20 to increase the hydrophilicity of the sterile filter.
Shreya Kapila +5 more
wiley +1 more source

