Results 81 to 90 of about 5,281 (192)

Large Language Models for Clinical Trial Protocol Assessments

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 393-402, February 2026.
The purpose was to evaluate the utility of large language models (LLMs) for reviewing the statistical analysis plan (SAP) and pharmacokinetics–pharmacodynamics (PK–PD) components of clinical trial protocols. Clinical trial protocols and SAPs were obtained from clinicaltrials.gov for a testbed of 15 small‐molecule drugs, biologics, and global antibiotic
Euibeom Shin, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. [PDF]

, 2016
The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59 ...
Zak, Daniel E, Del Giudice, Giuseppe, Nakaya, Helder I, Pollard, Andrew J, Cerundolo, Vincenzo, Dong, Tao, Siegrist, Claire-Anne, Cortese, Mario, Bosinger, Steven E, Clutterbuck, Elizabeth, Kazmin, Dmitri, Patel, Nirav B, Pulendran, Bali, Rappuoli, Rino, Wang, Lili, Aderem, Alan, Zak DE, Dong T, Pollard AJ, Wang L, Nakaya HI, Aderem A, Cerundolo V, Siegrist CA, Clutterbuck E, Cortese M, Kazmin D, Pulendran B, Del Giudice G, Patel NB, Bosinger SE, Rappuoli R   +31 more
core   +1 more source

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

Microbiology and Immunology, Volume 70, Issue 2, Page 68-79, February 2026.
ABSTRACT Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however ...
Nantaporn Kaewaroon, Sara Yoshimoto, Luthfi Muawan, Shintaro Shichinohe, Tokiko Watanabe   +4 more
wiley   +1 more source

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

, 2011
Oil-in-water emulsions have been successfully used to increase the efficacy, immunogenicity, and cross-protection of human vaccines; however, their mechanism of action is still largely unknown.
Annalisa Colaprico, Michele Pallaoro, Derek T. O'Hagan, Mariagrazia Pizza, Alessia Genovese, Laura Santini, Rino Rappuoli, Andreas Wack, Ennio De Gregorio, Susanna Aprea, Marzia M. Giuliani, Anja Seubert, Ugo D'Oro, Sara Valentini, Samuele Calabro, Barbara Galli   +15 more
core   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

MF59- and Al(OH)3-adjuvanted Staphylococcus aureus (4C-Staph) vaccines induce sustained protective humoral and cellular immune responses, with a critical role for effector CD4 T cells at low antibody titers.

Frontiers in Immunology, 2015
Staphylococcus aureus (S. aureus) is an important opportunistic pathogen that may cause invasive life-threatening infections like sepsis and pneumonia. Due to increasing antibiotic-resistance, the development of an effective vaccine against S.
Elisabetta eMonaci, Francesca eMancini, Francesca eMancini, Giuseppe eLofano, Giuseppe eLofano, Giuseppe eLofano, Marta eBacconi, Marta eBacconi, Simona eTavarini, Chiara eSammicheli, Letizia eArcidiacono, Monica eGiraldi, Bruno eGaletti, Silvia eRossi Paccani, Antonina eTorre, Maria Rita eFontana, Guido eGrandi, Guido eGrandi, Ennio eDe Gregorio, Giuliano eBensi, Emiliano eChiarot, Sandra eNuti, Fabio eBagnoli, Elisabetta eSoldaini, Sylvie eBertholet   +24 more
doaj   +1 more source

The issues caused by misinformation—How workers and organizations deal with it: A systematic literature review. An Annual Review of Information Science and Technology (ARIST) paper

Journal of the Association for Information Science and Technology, Volume 77, Issue 1, Page 133-162, January 2026.
Abstract In today's digital age, misinformation propagates rapidly through digital channels, blurring the lines between truth and fiction, and challenging the foundations of trust in information sources. Although affecting all spheres of life, misinformation poses a significant threat to workers highlighting a critical intersection between ...
Ashwani Malhotra, Nina Evans, Jing Gao, Jia Tina Du, Connie Zheng   +4 more
wiley   +1 more source

Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Human cytomegalovirus (HCMV)‐associated ocular diseases have gained increasing attention due to a recent rise in cases diagnosed in Asia. A glycoprotein encoded by the virus UL55 gene, glycoprotein B (gB), is essential for viral entry and a primary target for naturally‐produced antibodies and vaccine development.
Tantri Lestari, Nobuyo Yawata, Gabriel Gonzalez, Hiroko Miyadera, Daisuke Motooka, Yuko Imamura, Hiroya Oki, Yasuo Mori, Mariko Shirane, Seik‐Soon Khor, Yosuke Omae, Mihoko Shimada, Dyah Ayu Windy, Satoko Nakano, Hiroki Tsutsui, Shiori Kuramoto, Chihiro Fukui, Riku Nakamura, Satoshi Yamana, Toshikatsu Kaburaki, Hisashi Mashimo, Hiroshi Takase, Ryoji Yanai, Eiichi Hasegawa, Kensuke Shibata, Makoto Yawata, Katsushi Tokunaga, Nobuyuki Ohguro, Koh‐Hei Sonoda   +28 more
wiley   +1 more source

Trivalent and quadrivalent MF59(®)-adjuvanted influenza vaccine in young children : a dose- and schedule-finding study.

, 2011
Young children are at increased risk for influenza infections and related complications. The protection offered to children by conventional trivalent inactivated influenza vaccines (TIV) is suboptimal, due to poor immunogenicity and a higher exposure to ...
Nicolay, Uwe, Etienne Sokal, Giovanni Della Cioppa, Kelly Lindert, Uwe Nicolay, Sokal, Etienne, Timo Vesikari, Della Cioppa, Giovanni, Lindert, Kelly, Vesikari, Timo   +9 more
core   +1 more source

Astragalus polysaccharide loaded MF59 adjuvant system enhances vaccine-induced cellular immune responses

Nano Research
Vaccine adjuvants play a pivotal role in enhancing immune responses, but traditional adjuvants such as MF59 primarily induce humoral immunity and exhibit limited ability to activate CD8+ T cell-mediated cellular immunity. To address this critical gap, we
Ying Zhu, Sijie Wang, Huanli Zhou, YiChao Lu, Yitao Zhang, Xuemeng Guo, Qin Lin, Jiaxin Huang, Junlei Zhang, Lihua Luo, Chunqi Zhu, Jian You   +11 more
doaj   +1 more source