Results 71 to 80 of about 166,627 (157)

Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection

Journal of Immunology Research, 2020
Tuberculosis (TB) remains a major and global problem of public health. An effective TB subunit vaccine is urgently needed. Proper selection of the delivery system for the vaccine is crucial for inducing an appropriate immune response tailored to control ...
Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan   +7 more
doaj   +1 more source

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

Microbiology and Immunology, Volume 70, Issue 2, Page 68-79, February 2026.
ABSTRACT Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however ...
Nantaporn Kaewaroon, Sara Yoshimoto, Luthfi Muawan, Shintaro Shichinohe, Tokiko Watanabe   +4 more
wiley   +1 more source

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59

, 2011
Clinical studies have indicated that subvirion inactivated vaccines against avian influenza viruses, particularly H5N1, are poorly immunogenic in humans.
Christopher Lupfer, Ali H. Ellebedy, Thirumala-Devi Kanneganti, Jennifer DeBeauchamp, Richard J. Webby, Hazem E. Ghoneim, Lupfer, Christopher R., Webby, Richard J., Ellebedy, Ali H., Kanneganti, Thirumala Devi, Ghoneim, Hazem E., DeBeauchamp, Jennifer   +11 more
core   +1 more source

Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant

Pharmaceutics, 2019
Adjuvants enhance the efficacy of vaccines by stimulating immune response-related gene expression and pathways. Although some adjuvants have been approved for commercial use in human vaccines (e.g., Alum, MF59, and AS03), they might elicit adverse side ...
Hyeong-Jun Park, Hae Li Ko, Dong-Hoon Won, Da-Bin Hwang, Yoo-Sub Shin, Hye-Won Kwak, Hye-Jung Kim, Jun-Won Yun, Jae-Hwan Nam   +8 more
doaj   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

The issues caused by misinformation—How workers and organizations deal with it: A systematic literature review. An Annual Review of Information Science and Technology (ARIST) paper

Journal of the Association for Information Science and Technology, Volume 77, Issue 1, Page 133-162, January 2026.
Abstract In today's digital age, misinformation propagates rapidly through digital channels, blurring the lines between truth and fiction, and challenging the foundations of trust in information sources. Although affecting all spheres of life, misinformation poses a significant threat to workers highlighting a critical intersection between ...
Ashwani Malhotra, Nina Evans, Jing Gao, Jia Tina Du, Connie Zheng   +4 more
wiley   +1 more source

Silica Nanoparticles as Multifunctional Platforms for Vaccine Delivery and Immune Modulation in Infectious Diseases

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez, Julio García‐Cordero, Gabriela Navarro‐Tovar, Leticia Cedillo‐Barrón   +3 more
wiley   +1 more source

Immunogenicity and tolerability of an MF59-adjuvanted, egg-derived, A/H1N1 pandemic influenza vaccine in children 6-35 months of age [PDF]

, 2014
Background: Vaccines against pandemic A/H1N1 influenza should provide protective immunity in children, because they are at greater risk of disease than adults.
Rivera, L., Leroux-Roels, G., Abarca Villaseca, Katia, Arora, A., Knuf, M., Rumke, H., Pedotti, P., Lattanzi, M., Lattanzi, Maria, Pedotti, Paola, Kieninger-Baum, Dorothee, Knuf, Markus, Della Cioppa, Giovanni, Rivera, Luis, Abarca, Katia, Leroux-Roels, Geert, Rümke, Hans C, Arora, Ashwani   +17 more
core   +1 more source

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination [PDF]

, 2014
Vaccines are the most effective agents to control infections [1]. In addition to the pathogen antigens, vaccines contain adjuvants that are used to enhance the specific immune responses.
Vono, Maria
core  

MF59-adjuvanted influenza vaccine (FLUAD®) elicits higher immune responses than a non-adjuvanted influenza vaccine (Fluzone®): A randomized, multicenter, Phase III pediatric trial in Mexico

Human Vaccines & Immunotherapeutics, 2018
The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind, randomized Phase III trial assessed the immunogenicity and safety of the MF59-adjuvanted trivalent ...
Aurelio Cruz-Valdez, Gabriel Valdez-Zapata, Sanjay S. Patel, Flavia V. Castelli, Marcia G. Garcia, Wim T. Jansen, Ashwani Kumar Arora, Esther Heijnen   +7 more
doaj   +1 more source