Porphyromonas gingivalis FimA and Mfa1 fimbriae: Current insights on localization, function, biogenesis, and genotype [PDF]
Japanese Dental Science Review, 2021 In general, the periodontal pathogen Porphyromonas gingivalis expresses distinct FimA and Mfa1 fimbriae. Each of these consists of five FimA–E and five Mfa1–5 proteins encoded by the fim and mfa gene clusters, respectively.
Yoshiaki Hasegawa, Keiji Nagano
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Structural and antigenic characterization of a novel genotype of Mfa1 fimbriae in Porphyromonas gingivalis [PDF]
Journal of Oral Microbiology, 2023 Background Mfa1 fimbriae of the periodontal pathogen Porphyromonas gingivalis are responsible for biofilm formation and comprise five proteins: Mfa1–5. Two major genotypes, mfa170 and mfa153, encode major fimbrillin.
Miyuna Fujimoto +7 more
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Development of monoclonal antibodies against P. gingivalis Mfa1 and their protective capacity in an experimental periodontitis model [PDF]
mSpherePorphyromonas gingivalis (P. gingivalis), a gram-negative, black-pigmented anaerobe, is a major etiological agent and a leading cause of periodontitis. Fimbriae protein Mfa1 is a key virulence factor of P. gingivalis and plays a crucial role in bacterial
Mingya Cao +12 more
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Mfa4, an Accessory Protein of Mfa1 Fimbriae, Modulates Fimbrial Biogenesis, Cell Auto-Aggregation, and Biofilm Formation in Porphyromonas gingivalis [PDF]
PLoS ONE, 2015 Porphyromonas gingivalis, a gram-negative obligate anaerobic bacterium, is considered to be a key pathogen in periodontal disease. The bacterium expresses Mfa1 fimbriae, which are composed of polymers of Mfa1.
Yoshiaki Hasegawa +2 more
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Diversity analysis of genes encoding Mfa1 fimbrial components in Porphyromonas gingivalis strains
PLoS ONE, 2021 Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is associated with the development of periodontal disease. The genetic diversity in virulence factors, such as adhesive fimbriae, among its strains affects the bacterial pathogenicity.
Keiji Nagano, Yoshiaki Hasegawa
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High Molecular Weight Hyaluronic Acid Reduces the Expression of Virulence Genes fimA, mfa1, hagA, rgpA, and kgp in the Oral Pathogen Porphyromonas gingivalis [PDF]
Pharmaceutics, 2022 Porphyromonas gingivalis (P. gingivalis) is a cornerstone pathogen in the development and progression of periodontal and peri-implant tissue destruction. It is capable of causing dysbiosis of the microbial biofilm and modulation of the host immune system.
Meshal S. Alharbi, Fahad A. Alshehri
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Maturation of the Mfa1 Fimbriae in the Oral Pathogen Porphyromonas gingivalis
Frontiers in Cellular and Infection Microbiology, 2018 The Mfa1 fimbriae of the periodontal pathogen Porphyromonas gingivalis are involved in adhesion, including binding to synergistic species in oral biofilms.
Daniel P Miller +2 more
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Identification of the mechanism for dehalorespiration of monofluoroacetate in the phylum Synergistota [PDF]
Animal BioscienceObjective Monofluoroacetate (MFA) is a potent toxin that blocks ATP production via the Krebs cycle and causes acute toxicity in ruminants consuming MFA-containing plants.
Lex E. X. Leong +5 more
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Proteomics of Periodontitis-Associated Bacteria and Its Link to Oral Squamous Cell Carcinoma: A Contemporaneous Review [PDF]
International Dental Journal: Introduction and aims: Periodontitis, a chronic inflammatory disease of the periodontium, causes gingival inflammation and bone loss. Meanwhile, oral cancer synonymously known as oral squamous cell carcinoma is characterised by uncontrolled cell ...
ShueKang Yeong +3 more
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Phylogenomic analysis of the Porphyromonas gingivalis - Porphyromonas gulae duo: approaches to the origin of periodontitis [PDF]
Frontiers in Microbiology, 2023 Porphyromonas gingivalis is an oral human pathogen associated with the onset and progression of periodontitis, a chronic immune-inflammatory disease characterized by the destruction of the teeth-supporting tissue. P.
Mauricio Morales-Olavarría +8 more
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