Results 121 to 130 of about 534,915 (376)

Of LAP, CUPS and DRibbles – unconventional use of autophagy proteins for MHC restricted antigen presentation

Frontiers in Immunology, 2015
Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since MHC class II molecules are loaded with lysosomal products for CD4+ T cell stimulation, macroautophagy supports intracellular antigen processing onto MHC class II molecules.
Christian eMuenz
doaj   +1 more source

Segregation Analysis of Genotyped and Family-Phased, Long Range MHC Classical Class I and Class II Haplotypes in 5 Families With Type 1 Diabetes Proband in the United Arab Emirates [PDF]

, 2021
Guan K. Tay, Halima Al Naqbi, Aurélie Mawart, Zahrah Baalfaqih, Anoud Almaazmi, Asma Deeb, Habiba Alsafar   +6 more
openalex   +1 more source

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

eLife, 2014
Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells.
A. Baptista, R. Roozendaal, Rogier M. Reijmers, J. Koning, W. Unger, M. Greuter, E. Keuning, R. Molenaar, G. Goverse, M. Sneeboer, J. D. den Haan, M. Boes, R. Mebius   +12 more
semanticscholar   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: With particular emphasis on donor major histocompatibility complex class II⁺ cells [PDF]

, 2002
After a short course of tacrolimus, Lewis rat liver allografts induce donor-specific nonreactivity in Brown Norway recipients that is immunosuppression-independent after 28 days.
Anthony J. Demetris, Bishop, Calne, Cohn, Corry, Demetris, Demetris, Demetris, Demetris, Gill, Gould, Ichikawa, Iwaki, Jurcevic, Kamada, Ko, Larsen, Lechler, Lechler, Lu, Matzinger, Mosmann, Murase, Murase, Murase, Naoya Ichikawa, Nemlander, Nickerson, Noriko Murase, Ochsenbein, Olga Azhipa, Qian, Qian, Rogers, Russell, Sakamoto, Schlitt, Shoskes, Sims, Smith, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Takashi Ishikawa, Terakura, Thomas E. Starzl, Thomson, Toyokazu Okuda, Vremec, Wekerle, Womer, Wood, Yagihashi, Zinkernagel   +56 more
core   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Mouse CD4 binds MHC class II with extremely low affinity [PDF]

, 2017
Interaction of CD4 with MHC class II molecules plays a crucial role during thymic development and activation of singie-positive CD4 T lymphocytes. The quantitation of this interaction is, therefore, important for understanding the role of CD4 during ...
Karjalainen, Klaus, Weber, Susanna
core  

Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan [PDF]

, 2008
CD4 positive T helper cells control many aspects of specific immunity. These cells are specific for peptides derived from protein antigens and presented by molecules of the extremely polymorphic major histocompatibility complex (MHC) class II system. The
A Haque, A Sette, A Sette, A Sette, Alessandro Sette, B Boeckmann, B Peters, Bjoern Peters, C Lundegaard, C Sylvester-Hvid, Claus Lundegaard, D Middleton, F Castellino, H Noguchi, H Rammensee, H Singh, HH Bui, HM Berman, IA Doytchinova, J Alexander, J Cui, J Robinson, J Salomon, J Wan, JA Swets, JK Christensen, JW Yewdell, L Gauthier, M Moutaftsi, M Nielsen, M Nielsen, M Nielsen, M Nielsen, M Rajapakse, Morten Nielsen, N Murugan, O Karpenko, O Lund, Ole Lund, Ruth Nussinov, S Henikoff, SL Lauemoller, ST Chang, Sune Justesen, Søren Buus, T Sturniolo, Thomas Blicher, U Hobohm, V Brusic, WH Press   +49 more
core   +4 more sources

Tunicate‐Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age‐Associated Vocal Fold Atrophy

Advanced Healthcare Materials, EarlyView.
The pyrogallol‐conjugated carboxymethylcellulose (CMC‐PG) hydrogel is applicated as a filler for the treatment of presbylaryngis, a vocal fold atrophy. CMC‐PG provides a bulking effect to the vocal folds. CMC‐PG is readily injectable and tissue adhesive, enabling sustained release of growth factor over long period.
Jihoon Jeon, Sang‐Yoon Han, Ji Suk Choi, Soojeong Choi, Dongkyun Shin, Mikyung Shin, Seong Keun Kwon, Seung‐Woo Cho   +7 more
wiley   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source