Results 201 to 210 of about 135,004 (265)

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins. [PDF]

Melanoma Res
Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D.   +9 more
europepmc   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma. [PDF]

Clin Transl Med
Egea-Rodriguez S, Váraljai R, Nordmann TM, Lubis R, Philip M, Rambow F, Roesch A, Flaig M, Horn S, Stoll R, Zhao F, Paschen A, Klebl B, Hickson ID, Schadendorf D, Mann M, Helfrich I.   +16 more
europepmc   +1 more source

Dynamics of natural killer cell function upon recurrent stimulation

Biotechnology Progress, EarlyView.
Weekly stimulation of peripheral blood‐derived NK cells with engineered K562 feeder cells resulted in two distinct growth phases, shifting around Day 21–26. Cells in growth phase 2 exhibited slower growth, reduced metabolic activity, and lower cytotoxicity than cells from growth phase 1, which has implications for NK cell biomanufacturing.
Jennifer One, Janani Narayan, Frank Cichocki, Wei‐Shou Hu, Samira M. Azarin   +4 more
wiley   +1 more source

A major histocompatibility complex (MHC) class II molecule that binds the same viral pathogen peptide with both nonamer and decamer core sequences for presentation to T cells

Goryanin A, Cook AG, Behboudi S, Kaufman J, Halabi S.   +4 more
europepmc   +1 more source

PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages. [PDF]

Cell Rep
Pitter MR, Kryczek I, Zhang H, Nagarsheth N, Xia H, Wu Z, Tian Y, Okla K, Liao P, Wang W, Zhou J, Li G, Lin H, Vatan L, Grove S, Wei S, Li Y, Zou W.   +17 more
europepmc   +1 more source

How Does Academic Marginalization Impact Mental Well‐Being? Exploring the Mediating Roles of Vocational Identity and Occupational Engagement

The Career Development Quarterly, EarlyView.
ABSTRACT In an increasingly volatile global job market, students’ career development is shaped by both personal capacities and structural barriers. This study examined how academic marginalization—particularly related to educational background—influences the mental well‐being of South Korean college students, with attention to the mediating roles of ...
Eunjin Han
wiley   +1 more source

Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction. [PDF]

Clin Mol Hepatol
Dezhbord M, Kim SH, Park S, Lee DR, Kim N, Won J, Lee AR, Kim DS, Kim KH.   +8 more
europepmc   +1 more source

Asynchronous LGBTQ+ Affirming Counseling Training With Early Career Counselors: A Mixed Methods Program Evaluation

Counselor Education and Supervision, EarlyView.
ABSTRACT A growing body of research shows that training in LGBTQ+ affirming counseling (LGBTQ+ AC) positively impacts counselors’ perceived knowledge and skills in providing mental health services to LGBTQ+ communities. Existing program evaluations of LGBTQ+ AC, however, have primarily used synchronous delivery formats and cultural competency models ...
Amber L. Pope, Kelli Hartzell, Matt B. Siroty, Jeff Moe, Noelle St. Germain‐Sehr, Bianca R. Augustine, Amanda St. Germain‐Sehr, Tai Lexumé   +7 more
wiley   +1 more source

No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals. [PDF]

Proc Biol Sci
Tebbe J, Havenstein K, Forcada J, Tiedemann R, Caspers B, Hoffman JI.   +5 more
europepmc   +1 more source