NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction [PDF]
, 2009 The major histocompatibility complex (MHC) molecule plays a central role in controlling the adaptive immune response to infections. MHC class I molecules present peptides derived from intracellular proteins to cytotoxic T cells, whereas MHC class II ...
Morten Nielsen +35 more
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Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators [PDF]
The Journal of Immunology, 2011 Abstract Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains.
Parimal, Majumder, Jeremy M, Boss
openaire +2 more sources
The Major Histocompatibility Complex of Old World Camels—A Synopsis
Cells, 2019 This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil +5 more
doaj +1 more source
MHC class II tetramers made from isolated recombinant α and β chains refolded with affinity-tagged peptides. [PDF]
PLoS ONE, 2013 Targeting CD4+ T cells through their unique antigen-specific, MHC class II-restricted T cell receptor makes MHC class II tetramers an attractive strategy to identify, validate and manipulate these cells at the single cell level.
Peter Braendstrup +7 more
doaj +1 more source
Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins [PDF]
, 2016 Indexación: Web of ScienceThe evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class I deals
Dantas, GPM +7 more
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Antigen processing for MHC class II presentation via autophagy
Frontiers in Immunology, 2012 T cells recognize proteolytic fragments of antigens that are presented to them on major histocompatibility complex (MHC) molecules. MHC class I molecules present primarily products of proteasomal proteolysis to CD8+ T cells, while MHC class II molecules ...
Christian eMunz
doaj +1 more source
Schistosoma japonicum soluble egg antigens attenuate IFN-γ-induced MHC class II expression in RAW 264.7 macrophages. [PDF]
PLoS ONE, 2012 Innate immune response plays the key role in initiating and guiding the immune response. Elucidating the innate immune related molecular events involved in the interaction between the parasite and the host will aid in the development of an effective ...
Gui-Xia Tang +6 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2023 The aggregation of epitopes that are also able to bind major histocompatibility complex (MHC) alleles raises questions around the potential connection between the formation of epitope aggregates and their affinities to MHC receptors. We first performed a
Rodrigo Ochoa +4 more
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Identification of antigens presented by MHC for vaccines against tuberculosis [PDF]
, 2020 Mycobacterium tuberculosis (M.tb) is responsible for more deaths globally than any other pathogen. The only available vaccine, bacillus Calmette-Guérin (BCG), has variable efficacy throughout the world. A more effective vaccine is urgently needed.
Bettencourt, Paulo +14 more
core +1 more source
Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia. [PDF]
PLoS ONE, 2014 Major Histocompatibility Complex (MHC) class II genes encode for molecules that aid in the presentation of antigens to helper T cells. MHC characterisation within and between major vertebrate taxa has shed light on the evolutionary mechanisms shaping the
Weerachai Jaratlerdsiri +4 more
doaj +1 more source