Results 41 to 50 of about 11,994 (242)
Echinocandins – structure, mechanism of action and use in antifungal therapy
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 With increasing number of immunocompromised patients as well as drug resistance in fungi, the risk of fatal fungal infections in humans increases as well.
Mateusz Szymański +4 more
doaj +1 more source
Journal of Clinical Pharmacy and Therapeutics, 2021 Studies have demonstrated that ECMO leads to pharmacokinetic changes, with alterations in volume of distribution, clearance and drug sequestration by the circuit. We describe a successful dosing approach for daptomycin and micafungin for the treatment of
M. G. Cabanilla, Nicholas Villalobos
semanticscholar +1 more source
Antifungal Activity of Micafungin in Serum [PDF]
Antimicrobial Agents and Chemotherapy, 2009 ABSTRACT We have evaluated the antifungal activity of micafungin in serum by using the disk diffusion method with serum-free and serum-added micafungin standard curves. Serum samples from micafungin-treated patients have been shown to exhibit adequate antifungal activity, which was in proportion to both the applied dose and the actual ...
Satoshi Kishino +9 more
openaire +3 more sources
Microorganisms, 2023 Respiratory Syncytial Virus (RSV) is the top cause of infant hospitalization globally, with no effective treatments available. Researchers have sought small molecules to target the RNA-dependent RNA Polymerase (RdRP) of RSV, which is essential for ...
Eric Xu +4 more
doaj +1 more source
Journal of Fungi, 2021 Candiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three ...
Zuzana Javorova Rihova +2 more
semanticscholar +1 more source
Antimicrobial Agents and Chemotherapy, 2021 Scopulariopsis/Microascus isolates cause infections with high mortality in lung transplant recipients. Treatment is challenging due to antimicrobial resistance.
Ibai Los-Arcos +9 more
semanticscholar +1 more source
Journal of Infection in Developing Countries, 2018 Introduction: 1,3-β-D-glucan of the fungal cell wall and extracellular matrix (ECM) of Candida biofilm is also present as a periplasmic glucan and within the ECM of P. aeruginosa biofilm. Micafungin inhibits the synthesis of β-D-glucans.
Sari S Rasheed +4 more
doaj +1 more source
Breakthrough Invasive Candidiasis in Patients on Micafungin [PDF]
Journal of Clinical Microbiology, 2010 ABSTRACT For Candida species, a bimodal wild-type MIC distribution for echinocandins exists, but resistance to echinocandins is rare. We characterized isolates from patients with invasive candidiasis (IC) breaking through ≥3 doses of micafungin therapy during the first 28 months of its use at our center ...
Pfeiffer, Christopher D. +5 more
openaire +4 more sources
Medical Mycology Case Reports, 2020 We report a rare case of C. krusei knee arthritis treated with instillation of micafungin and arthroscopy. A 49-year-old man hospitalized for treatment of Acute Myeloid Leukemia developed knee arthritis with C. krusei.
Jeroen C. van Egmond +3 more
doaj
Pharmacokinetics of Micafungin in Critically Ill Patients [PDF]
Scientific Reports, 2019 AbstractWe investigated covariates of pharmacokinetics of micafungin in critically ill patients. After application of micafungin, plasma samples were collected. Non-linear mixed effects modelling (NONMEM 7.3) was used to develop the pharmacokinetic model. Using this model, the adequacy of a fixed 100 mg dosing regimen was evaluated in the study cohort.
Gastine, S +7 more
openaire +4 more sources