Фармакокинетика и ФармакодинамикаRelevance. Cyclo-L-prolylglycine (CPG), discovered as an endogenous compound in the central nervous system, is involved in the formation of a reaction to emotional stress in rodents with a pronounced fear reaction and has an analgesic effect in vivo ...
A. V. Nadorova +3 more
doaj +2 more sources
Comparison of Gut Microbiological Profiles of Inbred and Outbred Healthy Mice. [PDF]
MicrobiologyopenA meta‐analysis comparing four strains (inbred strains: C57BL and BALB; outbred strains: KM and ICR) of mouse healthy gut microbial 16S V3‐V4 data based on publicly available online data. ABSTRACT Gut microbes are closely related to host immunity and health, and mice are frequently used as a common model organism in biomedicine to study various ...
Liu X +12 more
europepmc +2 more sources
Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies. [PDF]
Eur J ImmunolMurine allergy model outcomes differ by sensitization route, allergen type, and mouse strain, influencing mechanisms such as IgE and mast cell involvement and the therapeutic relevance of each model. Understanding how experimental parameters shape outcomes is essential for selecting appropriate models and effectively translating findings to clinical ...
Nagata Y, Suzuki R.
europepmc +2 more sources
Evaluation of a modified triple-combination anesthesia using dexmedetomidine in mice. [PDF]
Animal Model Exp MedDevelopment of a modified ketamine‐free anesthetic (dMMB) using dexmedetomidine. To improve the safety and recovery profile of conventional MMB, we developed dMMB by replacing medetomidine with dexmedetomidine. This ketamine‐free formulation showed comparable anesthetic depth and enhanced thermoregulation, avoiding unnecessary isomers for safer use ...
Watanabe M +5 more
europepmc +2 more sources
Evaluation of Immunogenicity of Seasonal Influenza Split HA Vaccines Involved With Changes of Vaccine Strains Using Mouse and Human Sera. [PDF]
Microbiol ImmunolABSTRACT Seasonal influenza is prevalent every winter, and influenza vaccines are used to safeguard public health. As the influenza vaccines are produced in embryonated hen eggs using vaccine viruses recommended by the World Health Organization each year based on the epidemic situation, it is important, from the perspective of public health, to ...
Sato K +12 more
europepmc +2 more sources
Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER. [PDF]
Physiol RepStudy and results overview. Abstract Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain‐specific differences following voluntary wheel running exercise training in submaximal and maximal oxygen consumption (VO2), respiratory ...
Amiri N +4 more
europepmc +2 more sources
Maturation of the filariaLitomosoides sigmodontisin BALB/c mice; comparative susceptibility of nine other inbred strains [PDF]
Annales de Parasitologie Humaine et Comparée, 1992 When inoculated subcutaneously, the infective larvae of L. sigmodontis undergo complete development and produce a patent microfilaraemia in mice of the BALB background (BALB/c, BALB/K and BALB/B, with respectively the H-2d, H-2k et H-2b haplotypes). The most susceptible strain is BALB/c with all mice harbouring adult filariae and 47% of mice presenting
G, Petit +5 more
openaire +2 more sources
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior [PDF]
, 2015 Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ...
Borevitz, Justin O. +13 more
core +2 more sources
Experimentation with Animals: A Key Aspect of the 3Rs. The Genetic Quality [PDF]
, 2019 The genetic quality of laboratory animals is essential for reproducibility of scientific research. Working with animals of certifiedgenetic quality is still a pending issue in Argentina due to the lack of routine genetic controls, of information on the ...
Castillo, Nadia Sabiela +4 more
core +1 more source
Different mice inbred strains humoral immune response against human prostate-specific antigen [PDF]
The Ukrainian Biochemical Journal, 2019 The aim of the study was an investigation of humoral immune response to prostate-specific antigen (PSA) of different mice inbred strains for further development of recommendations for appropriate immunization schemes for monoclonal antibodies (McAbs ...
O. Yu. Galkin +2 more
doaj +1 more source