Role of cytokines, NO, and H2O2 on the immunopathology of Leptospirosis in genetically selected mice
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Immune response to leptospirosis is mainly humorally mediated, and involves opsonization of leptospires for phagocytosis by macrophages and neutrophils. However, some aspects are still unknown. For a more detailed analysis of the cellular immune response
M. Marinho +6 more
doaj +1 more source
Вопросы вирусологии, 2023 Introduction. Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is the lack of vaccines.
Ekaterina I. Lesnova +6 more
doaj +1 more source
Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage – Effect of mixed housing in complex environment [PDF]
, 2018 Developing reliable mouse models for social behaviour is challenging. Different tests have been proposed, but most of them consist of rather artificial confrontations of unfamiliar mice in novel arenas or are relying on social stress induced by ...
Heinla, Indrek +3 more
core +1 more source
Mitochondrial haplotype and sex modulate responses to endurance exercise training
The Journal of Physiology, EarlyView.Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn +8 more
wiley +1 more source
Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior
The Scientific World Journal, 2013 Recent studies strengthen the belief that physical activity as a behavior has a genetic basis. Screening wheel-running behavior in inbred mouse strains highlighted differences among strains, showing that even very limited genetic differences deeply ...
Dario Coletti +6 more
doaj +1 more source
Anatomic correlates of strial presbycusis in recombinant inbred mouse strains [PDF]
, 2010 This project attempts to identify anatomic features that predict the range of the ‘normal’ endocochlear potential in young inbred mice. Cochlear lateral wall histologic metrics were compared in recombinant inbred (RI) mouse strains formed from BALB/c and
Walkonis, Christina M
core +1 more source
Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. [PDF]
, 2016 We generated a CD8 T-cell receptor (TCR) transnuclear (TN) mouse specific to the Ld -restricted immunodominant epitope of GRA6 from Toxoplasma gondii as a source of cells to facilitate further investigation into the CD8 T-cell-mediated response against ...
Blanchard, Nicolas +7 more
core +2 more sources
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, Volume 13, Issue 22, 17 April 2026.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures [PDF]
Compr PhysiolPancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Li Y +8 more
europepmc +2 more sources
The contribution of natural killer complex loci to the development of experimental cerebral malaria.
PLoS ONE, 2014 BackgroundThe Natural Killer Complex (NKC) is a genetic region of highly linked genes encoding several receptors involved in the control of NK cell function.
Diana S Hansen +7 more
doaj +1 more source