Results 51 to 60 of about 80,040 (177)

Comparison of Metabolomic Profiles of Organs in Mice of Different Strains Based on SPME-LC-HRMS

Metabolites, 2020
Given that the extent to which genetics alters the metabolomic profile of tissues is still poorly understood, the current study aimed to characterize and investigate the metabolite profiles of brain, liver, kidney and skeletal muscle of two common mouse ...
Katarzyna Burlikowska, Iga Stryjak, Joanna Bogusiewicz, Bogumiła Kupcewicz, Karol Jaroch, Barbara Bojko   +5 more
doaj   +1 more source

CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Factors determining the onset and severity of chronic obstructive pulmonary disease remain poorly understood. Previous studies demonstrated that airway surface dehydration in βENaC-overexpressing (βENaC-Tg) mice on a mixed genetic background ...
Bjarki Johannesson, Stephanie Hirtz, Jolanthe Schatterny, Carsten Schultz, Marcus A Mall   +4 more
doaj   +1 more source

Investigation on bacterial lipopolysaccharide as immune system inducer on inbred Balb/c mice via nitric oxide pathway

Advanced Studies in Biology, 2015
Nitric oxide (NO) is one of dozens of lipophilic small molecules that is synthesized from amino acid L-Arginine, O2 and NADPH by nitric oxide synthase (NOS). There is increasing evidence that NO is an important molecular messenger involved in a wide variety of biological processes in different systems. One of the isoforms of NOS enzyme called inducible
Moslem Najafi, Hossein Nahrevanian, Shohreh Khatami, Nahid Masoudian, Mahin Farahmand   +4 more
openaire   +1 more source

Gamma‐irradiated Newcastle disease virus: an alternative inactivated oncolytic virotherapy

Immunology &Cell Biology, Volume 104, Issue 5, Page 473-484, May‐June 2026.
To overcome biological risks associated with using live NDV as an oncolytic therapy, we developed gamma‐NDV as a safer alternative. Using a murine model for skin cancer, we show that intratumor administration of gamma‐NDV outperformed live‐NDV in terms of reducing tumor growth and improving overall animal survival. Abstract Newcastle disease virus (NDV)
Eve V Kennedy, Yimin Chuah, Amal H Mostafa, Chloe J Gates, Jade Foeng, Todd S Norton, Shaun R McColl, Iain Comerford, Justin B Davies, Farhid Hemmatzadeh, Mohammed Alsharifi   +10 more
wiley   +1 more source

The Role of Apoptosis in the Cellular Response of Liver and Spleen of BALB/c Mice in Cutaneous Leishmaniasis

Iranian Journal of Medical Sciences, 2015
Background: Cutaneous leishmaniasis is a common parasitic disease in Iran being mainly caused by Leishmania (L.) major. The aim of this study was to investigate the occurrence of apoptosis in the spleen and liver of female mice infected with L.
Mahvash Jafari, Shanaz Shirbazou, Seyed Homayoon Sadraie, Gholamreza Kaka, Majid Norozi   +4 more
doaj  

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection

eLife, 2018
Both TH2-dependent helminth killing and suppression of the TH2 effector response have been attributed to macrophages (MΦ) activated by IL-4 (M(IL-4)). To investigate how M(IL-4) contribute to diverse infection outcomes, the MΦ compartment of susceptible ...
Sharon M Campbell, Johanna A Knipper, Dominik Ruckerl, Conor M Finlay, Nicola Logan, Carlos M Minutti, Matthias Mack, Stephen J Jenkins, Matthew D Taylor, Judith E Allen   +9 more
doaj   +1 more source

Analysis of structural variation among inbred mouse strains

BMC Genomics, 2023
Background ‘Long read’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic diseases.
Ahmed Arslan, Zhuoqing Fang, Meiyue Wang, Yalun Tan, Zhuanfen Cheng, Xinyu Chen, Yuan Guan, Laura J. Pisani, Boyoung Yoo, Gill Bejerano, Gary Peltz   +10 more
doaj   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, Volume 13, Issue 22, 17 April 2026.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Helminth Parasites of Conventionally Maintained Laboratory Mice: II- Inbred Strains with an Adaptation of the Anal Swab Technique

Memorias do Instituto Oswaldo Cruz, 1998
Worm burdens recovered from inbred mice strains, namely C57Bl/6, C57Bl/10, CBA, BALB/c, DBA/2 and C3H/He, conventionally maintained in two institutional animal houses in the State of Rio de Janeiro, RJ, Brazil, were analyzed and compared, regarding their
Lucineide Gonçalves, Roberto Magalhães Pinto, J Júlio Vicente, Dely Noronha, Delir Corrêa Gomes   +4 more
doaj   +1 more source

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li, Yingyu Wang, Bing Wang, Qin Ouyang, Weiqi Liu, Xiang Xu, Xu Zhang, Mingming Liu, Ruijuan Xiu   +8 more
wiley   +1 more source