Results 11 to 20 of about 80,040 (177)

The Inflammatory Response in the Murine Ovalbumin-Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences. [PDF]

Clin Transl Sci
ABSTRACT Valid pre‐clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low‐to‐moderate inflammatory responses with significant variability, undermining their validity and contributing to high drug attrition rates.
Henriksen IW, Bartholdy C, Koch J, Stefanova DV, Hansen CHF, Hansen AK.   +5 more
europepmc   +2 more sources

Maturation of the filariaLitomosoides sigmodontisin BALB/c mice; comparative susceptibility of nine other inbred strains [PDF]

Annales de Parasitologie Humaine et Comparée, 1992
When inoculated subcutaneously, the infective larvae of L. sigmodontis undergo complete development and produce a patent microfilaraemia in mice of the BALB background (BALB/c, BALB/K and BALB/B, with respectively the H-2d, H-2k et H-2b haplotypes). The most susceptible strain is BALB/c with all mice harbouring adult filariae and 47% of mice presenting
G, Petit, M, Diagne, P, Maréchal, D, Owen, D, Taylor, O, Bain   +5 more
openaire   +2 more sources

Study of protective properties of butyrylcholinesterase in acute anticholinesterase poisoning on BChE-KO and BALB/c mice [PDF]

Research Results in Pharmacology, 2020
Introduction: The article presents the results of studying the protective properties of recombinant human butyrylcholinesterase (rhBChE) in a model of acute anticholinesterase poisoning in mice knocked out for the BChE gene.
Viktor A. Palikov, Yuliya A. Palikova, Igor A. Dyachenko   +2 more
doaj   +3 more sources

Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice

Frontiers in Behavioral Neuroscience, 2007
Emotionally arousing experiences and stress influence cognitive processes and vice versa. Understanding the relations and interactions between these three systems forms the core of this study. We tested two inbred mouse strains (BALB/c, C57BL/6J; male; 3-
Vera Brinks, Maaike Van Der Mark, Ronald De Kloet, Melly S Oitzl   +3 more
doaj   +1 more source

The relationship between the content of the potential psychopharmacological agent cyclo-L-prolylglycine in the brain of experimental animals and its antihypoxic effect

Фармакокинетика и Фармакодинамика, 2020
In the study of strutural and intracellular distribution of cyclo-t-prolylglycine (CPG) in brain rats in experiments on mongrel white male rats, it was found that CPG determined more in the hippocampus and cerebral cortex with predominant localization in
V. P. Zherdev, S. S. Boyko, K. N. Kolyasnikova   +2 more
doaj   +1 more source

Assessment of Binge-Like Eating of Unsweetened vs. Sweetened Chow Pellets in BALB/c Substrains

Frontiers in Behavioral Neuroscience, 2022
Binge eating disorder (BED) is defined as chronic episodes of consuming large amounts of food in less than 2 h. Binge eating disorder poses a serious public health problem, as it increases the risk of obesity, type II diabetes, and heart disease.
Katherine D. Sena, Jacob A. Beierle, Kayla T. Richardson, Kathleen M. Kantak, Camron D. Bryant   +4 more
doaj   +1 more source

Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice

Scientific Reports, 2017
In this study, we examined how urine-borne volatile compounds (UVCs) and darcin of male mice are inherited from parents and interact to modulate the olfactory preferences of females using two inbred strains of mice, C57Bl/6 (C57) and BALB/c (BALB), and ...
Ying-Juan Liu, Hui-Fen Guo, Jian-Xu Zhang, Yao-Hua Zhang   +3 more
doaj   +1 more source

Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice

Neurobiology of Stress, 2019
The two strains of inbred mice, BALB/c and C57BL/6, are widely used in pre-clinical psychiatry research due to their differences in stress susceptibility.
Joshua McWhirt, Monica Sathyanesan, Dayalan Sampath, Samuel S. Newton   +3 more
doaj   +1 more source

Use of an antagonist of HMGB1 in mice affected by malignant mesothelioma: a preliminary ultrasound and optical imaging study

European Radiology Experimental, 2022
Background Malignant mesothelioma (MM) is an aggressive tumor, with a poor prognosis, usually unresectable due to late diagnosis, mainly treated with chemotherapy.
Massimo Venturini, Rosanna Mezzapelle, Salvatore La Marca, Laura Perani, Antonello Spinelli, Luca Crippa, Anna Colarieti, Anna Palmisano, Paolo Marra, Andrea Coppola, Federico Fontana, Giulio Carcano, Carlo Tacchetti, Marco Bianchi, Antonio Esposito, Massimo P. Crippa   +15 more
doaj   +1 more source

In vitro fertilization in inbred BALB/c mice II: effects of lactate, osmolarity and calcium on in vitro capacitation

In vitro fertilization in inbred BALB/c mice II: effects of lactate, osmolarity and calcium on in vitro capacitation, 2008
To elucidate requirements for in vitro sperm capacitation in inbred BALB/c mice, osmolarity, calcium and lactate were optimized using modified simplex optimization medium (mKSOM). Modified human tubal fluid (mHTF), a capacitation-supporting medium, was used as a control.
Seiji, Kito, Yuki, Ohta
openaire   +3 more sources