Results 111 to 120 of about 210,454 (234)
Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin
The FEBS Journal, EarlyView.The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura +8 more
wiley +1 more source
Neurobiology of Disease, 2002 Modifier genes may account for the phenotypic variability observed in the late-onset forms of globoid cell leukodystrophy (GCL) in humans. In order to begin a search for modifier genes, the effect of genetic background on the clinical and pathological ...
Sangita Biswas +3 more
doaj
Change in Recessive Lethal Alleles Frequency in Inbred Populations [PDF]
arXiv, 2013 In a population practicing consanguineous marriage, rare recessive lethal alleles (RRLA) have higher chances of affecting phenotypes. As inbreeding causes more homozygosity and subsequently more deaths, the loss of individuals with RRLA decreases the frequency of these alleles.
arxiv
On the Identifiability of Genetic Parameters for Growth in Mice With a Massively Deep Pedigree
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT In models with direct and maternal genetic effects, structural features of the data are a potential source of bias and low accuracy of estimates for genetic covariance parameters. One of the well‐known reasons for such poor practical identifiability is the lack of dams with own observations.
X. Ding, A. A. Musa, N. Reinsch
wiley +1 more source
The pattern and distribution of deleterious mutations in maize [PDF]
arXiv, 2013 Most non-synonymous mutations are thought to be deleterious because of their effect on protein sequence. These polymorphisms are expected to be removed or kept at low frequency by the action of natural selection, and rare deleterious variants have been implicated as a possible explanation for the "missing heritability" seen in many studies of complex ...
arxiv
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Immunomodulation of salivary gland function due to cancer therapy
Oral Diseases, EarlyView.Abstract Functional salivary glands (SG) are essential for maintaining oral health, and salivary dysfunction is a persistent major clinical challenge. Several cancer therapies also have off‐target effects leading to SG dysfunction. Recent advances highlight the role of SG immune populations in homeostasis, dysfunction and gland regeneration.
Ana C. Costa‐da‐Silva +3 more
wiley +1 more source
Fast Computation of the Kinship Coefficients [PDF]
arXiv, 2016 For families, kinship coefficients are quantifications of the amount of genetic sharing between a pair of individuals. These coefficients are critical for understanding the breeding habits and genetic diversity of diploid populations. Historically, computations of the inbreeding coefficient were used to prohibit inbred marriages and prohibit breeding ...
arxiv
Phase Transition in Sexual Reproduction and Biological Evolution [PDF]
, 2008 Using Monte Carlo model of biological evolution we have discovered that populations can switch between two different strategies of their genomes' evolution; Darwinian purifying selection and complementing the haplotypes. The first one is exploited in the large panmictic populations while the second one in the small highly inbred populations. The choice
arxiv +1 more source
Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]
, 2004 Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K. +4 more
core +1 more source