Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity [PDF]
BMC Neuroscience, 2005 Background Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body.
Wu Fangbai +4 more
doaj +8 more sources
Geometric morphometrics defines shape differences in the cortical area map of C57BL/6J and DBA/2J inbred mice [PDF]
BMC Neuroscience, 2006 Background We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity.
Guan Monica +3 more
doaj +7 more sources
Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder. [PDF]
Genes Brain BehavCore symptoms of human DCD modeled in BXD recombinant inbred strains of mice. Significant strain differences for all measures of motor coordination were found. Three significant quantitative trait loci and seven candidate genes for gait were identified.
Rajan JRS +6 more
europepmc +2 more sources
Host genetic background strongly influences the response to influenza a virus infections. [PDF]
PLoS ONE, 2009 The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the ...
Barkha Srivastava +7 more
doaj +7 more sources
Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice [PDF]
Frontiers in Behavioral Neuroscience, 2020 Sensation seeking is a heritable trait that is genetically correlated with substance use; the shared genetic mechanisms underlying these traits are largely unknown.
Price E. Dickson, Guy Mittleman
doaj +3 more sources
Identification of ethanol analgesia quantitative trait loci and candidate genes in BXD recombinant inbred mouse lines. [PDF]
Addict BiolThe genetic basis for analgesic properties of alcohol was studied using the BXD panel of mice and identified multiple areas of the genome influencing alcohol analgesia. By combining this genetic mapping with bioinformatic analyses of existing pain literature, candidate genes were prioritized and identified Myo6 as a potential regulator of alcohol ...
Rogers WD +3 more
europepmc +2 more sources
Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol? [PDF]
Frontiers in PsychiatryUnder conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed +4 more
doaj +2 more sources
Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice [PDF]
BMC Neuroscience, 2007 Background Several neurodegenerative diseases are influenced by complex genetics that affect an individual's susceptibility, disease severity, and rate of progression.
Schlamp Cassandra L +3 more
doaj +5 more sources
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains [PDF]
Fluids and Barriers of the CNS, 2021 Background Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants.
Johanna Schaffenrath +4 more
doaj +3 more sources
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis [PDF]
Bone ResearchRheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally acquired and associated with RA susceptibility.
Hongzhen Chen +17 more
doaj +2 more sources