Results 11 to 20 of about 19,905 (224)

Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure [PDF]

Scientific Reports
Drug addiction is a multifactorial syndrome in which genetic predispositions and exposure to environmental stressors constitute major risk factors for the early onset, escalation, and relapse of addictive behaviors.
Carole Morel, Lyonna F. Parise, Yentl Y. Van der Zee, Orna Issler, Min Cai, Caleb J. Browne, Anthony Blando, Katherine B. LeClair, Antonio V. Aubry, Sherod Haynes, Robert W. Williams, Megan K. Mulligan, Scott J. Russo, Eric J. Nestler, Ming-Hu Han   +14 more
doaj   +2 more sources

Very mild disease phenotype of congenic Cftr^{TgH(neoim)Hgu} cystic fibrosis mice [PDF]

BMC Genetics, 2008
Background A major boost to cystic fibrosis disease research was given by the generation of various mouse models using gene targeting in embryonal stem cells. Moreover, the introduction of the same mutation on different inbred strains generating congenic
Leonhard-Marek Sabine, Burmester Marion, Bot Alice, Charizopoulou Nikoletta, Wedekind Dirk, Jansen Silke, Dorsch Martina, Stanke Frauke, Wilke Martina, Tóth Balázs, de Jonge Hugo R, Hedrich Hans-Jürgen, Breves Gerhard, Tümmler Burkhard   +13 more
doaj   +8 more sources

Susceptibility Analysis in Several Mouse Strains Reveals Robust T-Cell Responses After Mycoplasma pneumoniae Infection in DBA/2 Mice

Frontiers in Cellular and Infection Microbiology, 2021
Mycoplasma pneumoniae (Mp) is a highly contagious respiratory pathogen responsible for human community-acquired pneumonia. The number of antibiotic-resistant Mp strains is increasing; therefore, to develop novel therapeutics, it is crucial to precisely ...
Shigeyuki Tamiya, Shigeyuki Tamiya, Shigeyuki Tamiya, Eisuke Yoshikawa, Eisuke Yoshikawa, Eisuke Yoshikawa, Koichiro Suzuki, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +11 more
doaj   +1 more source

Behavioral and Metabolome Differences between C57BL/6 and DBA/2 Mouse Strains: Implications for Their Use as Models for Depression- and Anxiety-Like Phenotypes

Metabolites, 2021
Mouse models are widely used to study behavioral phenotypes related to neuropsychiatric disorders. However, different mouse strains vary in their inherent behavioral and molecular characteristics, which needs to be taken into account depending on the ...
Michaela D. Filiou, Markus Nussbaumer, Larysa Teplytska, Christoph W. Turck   +3 more
doaj   +1 more source

Lipopolysaccharide‐Induced Bone Loss in Rodent Models: A Systematic Review and Meta‐Analysis

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 198-213, January 2023., 2023
ABSTRACT Osteoporosis has traditionally been characterized by underlying endocrine mechanisms, though evidence indicates a role of inflammation in its pathophysiology. Lipopolysaccharide (LPS), a component of gram‐negative bacteria that reside in the intestines, can be released into circulation and stimulate the immune system, upregulating bone ...
Kirsten N. Bott, Evelyn Feldman, Russell J. de Souza, Elena M. Comelli, Panagiota Klentrou, Sandra J. Peters, Wendy E. Ward   +6 more
wiley   +1 more source

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases. [PDF]

PLoS ONE, 2012
Mouse embryonic stem (ES) cells are derived from the inner cell mass of blastocyst stage embryos and are used primarily for the creation of genetically engineered strains through gene targeting.
Laura G Reinholdt, Gareth R Howell, Anne M Czechanski, Danilo G Macalinao, Katharine H Macnicoll, Chyuan-Sheng Lin, Leah Rae Donahue, Simon W M John   +7 more
doaj   +1 more source

Chronobiology of alcohol: Studies in C57BL/6J and DBA/2J inbred mice [PDF]

Physiology & Behavior, 2013
Human alcoholics display dramatic disruptions of circadian rhythms that may contribute to the maintenance of excessive drinking, thus creating a vicious cycle. While clinical studies cannot establish direct causal mechanisms, recent animal experiments have revealed bidirectional interactions between circadian rhythms and ethanol intake, suggesting that
Michael C. Fixaris, Alan M. Rosenwasser
openaire   +3 more sources

CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey, Jayshen Arudkumar, Annemieke Aartsma‐Rus, Fatwa Adikusuma, Paul Q. Thomas   +4 more
wiley   +1 more source

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

mBio, 2022
Host genetic determinants that underpin variation in susceptibility to systemic fungal infection are poorly understood. Genes responsible for complex traits can be identified by correlating variation in phenotype with allele in founder strains of wild ...
Elaine M. Kohn, Cleison Taira, Hanah Dobson, Lucas Dos Santos Dias, Uju Okaa, Darin L. Wiesner, Marcel Wüthrich, Bruce S. Klein   +7 more
doaj   +1 more source

Epigenetic Clocks for Mice Based on Age-Associated Regions That are Conserved Between Mouse Strains and Human

Frontiers in Cell and Developmental Biology, 2022
Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice.
Juan-Felipe Perez-Correa, Juan-Felipe Perez-Correa, Vithurithra Tharmapalan, Vithurithra Tharmapalan, Hartmut Geiger, Wolfgang Wagner, Wolfgang Wagner   +6 more
doaj   +1 more source