Results 31 to 40 of about 19,573 (206)
Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]
, 2004 Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S. +7 more
core +5 more sources
High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]
, 2015 Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A +6 more
core +1 more source
Laboratory Animal Research, 2018 Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a ...
Hajin Nam +5 more
doaj +1 more source
Genetic background modulates the phenotype of a mouse model of DYT1 dystonia. [PDF]
PLoS ONE, 2012 DYT1 dystonia is a debilitating neurological disease characterized by involuntary twisting movements. The disease is caused by an in-frame deletion (GAG, "ΔE") mutation in the TOR1A gene that encodes the torsinA protein.
Lauren M Tanabe +2 more
doaj +1 more source
Normal spatial learning and improved spatial working memory in mice (mus musculus) lacking dopamine d4 receptors [PDF]
, 2001 Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor ...
Avale, Maria Elena +3 more
core +1 more source
Genetic analysis of cholesterol accumulation in inbred mice
Journal of Lipid Research, 2001 Genetic linkage analysis in the laboratory mouse identified chromosomal regions containing genes that contribute to cholesterol accumulation in the liver and plasma.
Margrit Schwarz +3 more
doaj +1 more source
Вопросы вирусологии, 2023 Introduction. Hepatitis C is a liver disease with high chronicity, the cause of cirrhosis and hepatocarcinoma. The main obstacle to controlling hepatitis C is the lack of vaccines.
Ekaterina I. Lesnova +6 more
doaj +1 more source
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner [PDF]
, 2012 Background There is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a ...
Alberts, R. +8 more
core +5 more sources
Frontiers in Behavioral Neuroscience, 2016 Flexibility in using different learning strategies was assessed in two different inbred strains of mice, the C57BL/6 and DBA/2 strains. Mice were trained sequentially in two different Morris water maze protocols that tested their ability to switch their ...
Woo-Hyun Cho, Jung-Soo Han
doaj +1 more source
Strain Differences in Developmental Vulnerability to Alcohol Exposure Via Embryo Culture in Mice [PDF]
, 2011 Background Prenatal alcohol exposure can result in varying degrees of neurodevelopmental deficits, growth retardation, and facial dysmorphology. Variation in these adverse outcomes not only depends on the dose and pattern of alcohol exposure but also on
Chen, Yuanyuan +4 more
core +2 more sources