Results 41 to 50 of about 13,850 (186)
AbstractNicotine is the reinforcing ingredient in tobacco. Following chronic exposure, sudden cessation of nicotine use produces negative symptoms of withdrawal that contribute to dependence. The molecular mechanisms underlying nicotine withdrawal behaviors, however, are poorly understood.
Maren L. Smith+5 more
openaire +2 more sources
Genetic background modulates the phenotype of a mouse model of DYT1 dystonia. [PDF]
DYT1 dystonia is a debilitating neurological disease characterized by involuntary twisting movements. The disease is caused by an in-frame deletion (GAG, "ΔE") mutation in the TOR1A gene that encodes the torsinA protein.
Lauren M Tanabe+2 more
doaj +1 more source
GENETIC ANALYSIS OF AUDIOGENIC SEIZURE SUSCEPTIBILITY IN C57BL/6J x DBA/2J RECOMBINANT INBRED STRAINS OF MICE [PDF]
ABSTRACT The inheritance of susceptibility to audiogenic seizures (ASS) was studied in the C57BW6J (B6) and DBA/2j (D2) progenitor strains, their reciprocal F1 hybrids, backcross generations and in 21 B6 × D2 recombinant inbred (RI) strams of mice at 21 days of age.
Seyfried, T N, Yu, R K, Glaser, G H
openaire +3 more sources
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed to obtain data on the characteristics of a ...
Hajin Nam+5 more
doaj +1 more source
Kripke Contexts, Double Boolean Algebras with Operators and Corresponding Modal Systems [PDF]
The notion of a context in formal concept analysis and that of an approximation space in rough set theory are unified in this study to define a Kripke context. For any context (G,M,I), a relation on the set G of objects and a relation on the set M of properties are included, giving a structure of the form ((G,R), (M,S), I).
arxiv
Demonstration of a low latency bandwidth allocation mechanism for mission critical applications in virtual PONs with P4 programmable hardware [PDF]
We provide a real-time demonstration of a low-latency PON DBA mechanism, optimised for virtual PONs. Our implementation mixes P4 programmable data plane and software-based virtual DBA to provide efficient fast-track allocation for low latency ...
arxiv
Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice
The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo+4 more
doaj +1 more source
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
A Novel low-latency DBA for Virtualised PON implemented through P4 In-Network Processing [PDF]
We present a novel dual-DBA allocation, with a fast P4-enabled scheduler to provide low latency upstream grant allocations.
arxiv
Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains
Background Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants.
Johanna Schaffenrath+4 more
doaj +1 more source