Results 51 to 60 of about 13,850 (186)

Technetium-99m pyrophosphate uptake in spontaneously occurring perimyocardial lesions in an inbred strain of DBA/2 mice.

Japanese Circulation Journal, 1982
The spontaneous occurrence of perimyocardial calcification localized in the right ventricle has been reported in an inbred strain of DBA/2 mice. In this paper we examined the correlation between the myocardial uptake ratio of technetium-99m pyrophosphate (99mTc-PYP) and pathological findings in these mice ranging in age from one to 12 months and became
Kanji Torizuka, Akira Matsumori, Akira Yoshida, Chuichi Kawai   +3 more
openaire   +4 more sources

Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

BMC Neuroscience, 2007
Background Several neurodegenerative diseases are influenced by complex genetics that affect an individual's susceptibility, disease severity, and rate of progression.
Schlamp Cassandra L, Semaan Sheila J, Li Yan, Nickells Robert W   +3 more
doaj   +1 more source

To Tweak or Not to Tweak. How Exploiting Flexibilities in Gene Set Analysis Leads to Overoptimism

Biometrical Journal, Volume 67, Issue 1, February 2025.
ABSTRACT Gene set analysis, a popular approach for analyzing high‐throughput gene expression data, aims to identify sets of genes that show enriched expression patterns between two conditions. In addition to the multitude of methods available for this task, users are typically left with many options when creating the required input and specifying the ...
Milena Wünsch, Christina Sauer, Moritz Herrmann, Ludwig Christian Hinske, Anne‐Laure Boulesteix   +4 more
wiley   +1 more source

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

PLoS Genetics, 2012
Atrio-ventricular conduction disease is a common feature in Mendelian rhythm disorders associated with sudden cardiac death and is characterized by prolongation of the PR interval on the surface electrocardiogram (ECG). Prolongation of the PR interval is
Elisabeth M Lodder, Brendon P Scicluna, Annalisa Milano, Albert Y Sun, Hao Tang, Carol Ann Remme, Perry D Moerland, Michael W T Tanck, Geoffrey S Pitt, Douglas A Marchuk, Connie R Bezzina   +10 more
doaj   +1 more source

Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10 [PDF]

Genes & Immunity, 2003
A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that ...
Sheher Sun, X Yang, Nengjun Yi, P-A Yang, Xin Xu, Lu Lu, H-C Hsu, H. G. Zhang, H. G. Zhang, Lina Li, Juling Zhou, David B. Allison, G Van Zant, Robert W. Williams, John D. Mountz, John D. Mountz, Qi Wu   +16 more
openaire   +3 more sources

Genetic analysis of intestinal cholesterol absorption in inbred mice

Journal of Lipid Research, 2001
A genetic mapping strategy was employed to identify chromosomal regions harboring genes that influence the absorption of intestinal cholesterol in the mouse.
Margrit Schwarz, Daphne L. Davis, Bertrand R. Vick, David W. Russell   +3 more
doaj  

Discovery of Novel Pain Regulators Through Integration of Cross‐Species High‐Throughput Data

CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
Cross‐species analysis was used to identify novel pain mediators based on human DRG expression profiles and RNA‐seq data from a mouse model of neuropathic pain injury. ABSTRACT Aims Chronic pain is an impeding condition that affects day‐to‐day life and poses a substantial economic burden, surpassing many other health conditions.
Ying Chen, Akhilesh K. Bajpai, Nan Li, Jiahui Xiang, Angelina Wang, Qingqing Gu, Junpu Ruan, Ran Zhang, Gang Chen, Lu Lu   +9 more
wiley   +1 more source

Atp1a2 and Kcnj9 Are Candidate Genes Underlying Sensitivity to Oxycodone‐Induced Locomotor Activation and Withdrawal‐Induced Anxiety‐Like Behaviors in C57BL/6 Substrains

Genes, Brain and Behavior, Volume 24, Issue 1, February 2025.
We exploited near‐isogenic C57BL/6 substrains to fine‐map a 2.45‐Mb region containing DNA variants underlying oxycodone behaviors. We mapped a genomic region on distal chromosome 1 and identified genotype‐driven, differentially expressed mRNAs and proteins within this region and DNA variants.
Lisa R. Goldberg, Britahny M. Baskin, Jacob A. Beierle, Yahia Adla, Julia C. Kelliher, Emily J. Yao, Stacey L. Kirkpatrick, Eric R. Reed, David F. Jenkins, Jiayi Cox, Alexander M. Luong, Kimberly P. Luttik, Julia A. Scotellaro, Timothy A. Drescher, Sydney B. Crotts, Neema Yazdani, Martin T. Ferris, W. Evan Johnson, Megan K. Mulligan, Camron D. Bryant   +19 more
wiley   +1 more source

The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment [PDF]

, 2012
The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam.
arxiv   +1 more source

Missing Value Estimation using Clustering and Deep Learning within Multiple Imputation Framework [PDF]

arXiv, 2022
Missing values in tabular data restrict the use and performance of machine learning, requiring the imputation of missing values. The most popular imputation algorithm is arguably multiple imputations using chains of equations (MICE), which estimates missing values from linear conditioning on observed values.
arxiv