Results 51 to 60 of about 19,573 (206)

Immobilization induced osteopenia is strain specific in mice

Bone Reports, 2015
Immobilization causes rapid and massive bone loss. By comparing Botulinum Toxin A (BTX)-induced bone loss in mouse strains with different genetic backgrounds we investigated whether the genetic background had an influence on the severity of the ...
Andreas Lodberg, Jens Bay Vegger, Michael Vinkel Jensen, Christian Mirian Larsen, Jesper Skovhus Thomsen, Annemarie Brüel   +5 more
doaj   +1 more source

Host stress drives Salmonella recrudescence [PDF]

, 2016
Host stress is well known to result in flare-ups of many bacterial, viral and parasitic infections. The mechanism by which host stress is exploited to increase pathogen loads, is poorly understood.
Bert, Wim, Boyen, Filip, Deforce, Dieter, Dhaenens, Maarten, Favoreel, Herman, Haesebrouck, Freddy, Haesendonck, Roel, Leyman, Bregje, Pasmans, Frank, Shearer, Neil, Thompson, Arthur, Van Parys, Alexander, Verbrugghe, Elin   +12 more
core   +2 more sources

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, Volume 66, Issue 12, Page 4983-4995, December 2025.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes

Journal of Lipid Research, 1995
A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk.
E A Kirk, G L Moe, M T Caldwell, J A Lernmark, D L Wilson, R C LeBoeuf   +5 more
doaj   +1 more source

Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice

Scientific Reports, 2023
The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo, Sarah Brunty, Jessica Huffman, Alexis Kastigar, Price E. Dickson   +4 more
doaj   +1 more source

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]

, 2016
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta, Gong, Ke Wei, Lusis, Aldons J, Rau, Christoph, Ren, Shuxun, Romay, Milagros C, Stolin, Gabriel, Wang, Jessica Jen-Chu, Wang, Yibin   +8 more
core   +3 more sources

Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains

Fluids and Barriers of the CNS, 2021
Background Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants.
Johanna Schaffenrath, Sheng-Fu Huang, Tania Wyss, Mauro Delorenzi, Annika Keller   +4 more
doaj   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice [PDF]

, 2000
Genes influencing body weight and composition and serum concentrations of leptin, insulin, and insulin-like growth factor I (IGF-I) in nonfasting animals were mapped in an intercross of the extreme high-growth mouse line DU6i and the inbred line DBA/2 ...
Brockmann, G A, Haley, C S, Karle, S, Kratzsch, J, Renne, U, Schwerin, M   +5 more
core   +2 more sources

Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose‐mediated peritoneal injury in mice

Physiological Reports, Volume 13, Issue 22, November 2025.
High‐glucose peritoneal dialysis (PD) fluid induces oxidative stress, inflammation, and fibrosis in the peritoneum. In vivo, Nnt‐deficient C57BL/6J mice showed significantly reduced PD‐induced peritoneal injury, inflammation, and fibrosis compared with Nnt‐competent C57BL/6N controls.
Margarete C. Ohse, Song Rong, Sonja Schmidt, Michael S. Balzer, Christoph Nikolin, Sibylle von Vietinghoff, Hermann Haller, Kai M. Schmidt‐Ott, Yulia Kiyan, Nelli Shushakova   +9 more
wiley   +1 more source