Results 61 to 70 of about 19,573 (206)

Mouse models of colorectal cancer. [PDF]

, 2011
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip, Tong, Yunguang, Yang, Wancai   +2 more
core   +2 more sources

Metabolic Adaptations of Three Inbred Strains of Mice (C57BL/6, DBA/2, and 129T2) in Response to a High-Fat Diet [PDF]

The Journal of Nutrition, 2004
Although it is now becoming more evident that the strain of mouse used to generate genetically modified models for the study of endocrine disorders contributes to the ensuing phenotype, metabolic characterization of these common strains used to produce genetically altered mice has been limited.
Alexandra, Funkat, Christine M, Massa, Valentina, Jovanovska, Joseph, Proietto, Sofianos, Andrikopoulos   +4 more
openaire   +2 more sources

Enhancing sudden unexpected death in epilepsy (SUDEP) research through development of common data elements

Epilepsia Open, Volume 10, Issue 5, Page 1426-1438, October 2025.
Abstract Objective Sudden Unexpected Death in Epilepsy (SUDEP) is a fatal complication for individuals living with epilepsy and is associated with significant personal and public burden. While certain neurotransmitters and neuronal pathways have been associated with SUDEP, the exact biological mechanisms are unknown.
Sloka S. Iyengar, Elaine K. O'Loughlin, Lauren Harte‐Hargrove, Mary Holmay, Laura S. Lubbers, CURE Epilepsy SUDEP Data Standardization Project Steering Committee, CURE Epilepsy SUDEP Data Standardization Project Working Group Members, Lisa M. Bateman, Edward Glasscock, Samden Lhatoo, Philippe Ryvlin, Kristina Simeone, Charles Akos Szabo, Melanie Whittamore‐Mantzios, David Auerbach, Gordon Buchanan, Jeffrey Buchhalter, Beate Diehl, Elizabeth Donner, Carl Faingold, Daniel Friedman, Christina Gross, Bin Gu, Franck Kalume, David Ryan King, Nuria Lecumberri, Susanne Mueller, William Nobis, Jeffrey Noebels, Terence O’Brien, Manoj Patel, George Richerson, Steven Schachter, Timothy Simeone, Ian Wenker   +34 more
wiley   +1 more source

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

PLoS Genetics, 2012
Atrio-ventricular conduction disease is a common feature in Mendelian rhythm disorders associated with sudden cardiac death and is characterized by prolongation of the PR interval on the surface electrocardiogram (ECG). Prolongation of the PR interval is
Elisabeth M Lodder, Brendon P Scicluna, Annalisa Milano, Albert Y Sun, Hao Tang, Carol Ann Remme, Perry D Moerland, Michael W T Tanck, Geoffrey S Pitt, Douglas A Marchuk, Connie R Bezzina   +10 more
doaj   +1 more source

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis. [PDF]

, 2016
Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eskin, Eleazar, Han, Buhm, Kang, Eun Yong, Li, Xiao, Park, Yurang, Segrè, Ayellet V   +5 more
core   +3 more sources

Sex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER

Physiological Reports, Volume 13, Issue 19, October 2025.
Study and results overview. Abstract Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain‐specific differences following voluntary wheel running exercise training in submaximal and maximal oxygen consumption (VO2), respiratory ...
N. Amiri, H. Zhang, R. McMillan, R. W. Grange, J. C. Drake   +4 more
wiley   +1 more source

Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

BMC Neuroscience, 2007
Background Several neurodegenerative diseases are influenced by complex genetics that affect an individual's susceptibility, disease severity, and rate of progression.
Schlamp Cassandra L, Semaan Sheila J, Li Yan, Nickells Robert W   +3 more
doaj   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

A high-resolution single nucleotide polymorphism genetic map of the mouse genome [PDF]

, 2006
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans.
Bell, Jordana Tzenova, Copley, Richard R., Flint, Jonathan, Gibbs, Richard, Mott, Richard, Shifman, Sagiv, Taylor, Martin S., Williams, Robert W.   +7 more
core   +7 more sources

Quantitative Trait Loci Analysis of Structural and Material Skeletal Phenotypes in C57BL/6J and DBA/2 Second-Generation and Recombinant Inbred Mice [PDF]

Journal of Bone and Mineral Research, 2005
Abstract QTL analyses identified several chromosomal regions influencing skeletal phenotypes of the femur and tibia in BXD F2 and BXD RI populations of mice. QTLs for skeletal traits co-located with each other and with correlated traits such as body weight and length, adipose mass, and serum alkaline phosphatase ...
Lang, Dean H., Sharkey, Neil A., Mack, Holly A. (R18996), Vogler, George P., Vandenbergh, David J., Blizard, David A., Stout, Joseph T., McClearn, Gerald E.   +7 more
openaire   +3 more sources