Results 71 to 80 of about 19,573 (206)

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, Volume 10, Issue S1, Page S40-S52, August 2025.
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

The TP53 tumor suppressor gene: From molecular biology to clinical investigations

Journal of Internal Medicine, Volume 298, Issue 2, Page 78-96, August 2025.
Abstract Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in human malignancies, 50% of which carry alterations to it.
Panagiotis Baliakas, Thierry Soussi
wiley   +1 more source

MYH6‐Cre Insertion Accelerates Cardiac Phenotype in Dystrophic D2‐mdx Mice

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
D2.B10‐Dmdmdx/J dystrophic mice were crossed with Tg(myh6‐cre)1Jmk/J mice to create a cardiac‐specific Myh6‐cre (Cre+) promoter region on the D2‐mdx background. Cre+ dystrophic animals demonstrate worse right and left ventricular systolic function, which correlates with increased cardiac‐specific fibrosis and ultimately reduced survival.
India K. Hawkins, Trung Phi, Joshua Mitchell, Frank Corwin, Adolfo G. Mauro, Fadi N. Salloum, Frank J. Raucci Jr.   +6 more
wiley   +1 more source

Helminth Parasites of Conventionally Maintained Laboratory Mice: II- Inbred Strains with an Adaptation of the Anal Swab Technique

Memorias do Instituto Oswaldo Cruz, 1998
Worm burdens recovered from inbred mice strains, namely C57Bl/6, C57Bl/10, CBA, BALB/c, DBA/2 and C3H/He, conventionally maintained in two institutional animal houses in the State of Rio de Janeiro, RJ, Brazil, were analyzed and compared, regarding their
Lucineide Gonçalves, Roberto Magalhães Pinto, J Júlio Vicente, Dely Noronha, Delir Corrêa Gomes   +4 more
doaj   +1 more source

Identification of Novel Potential Type 2 Diabetes Genes Mediating β-Cell Loss and Hyperglycemia Using Positional Cloning

Frontiers in Genetics, 2020
Type 2 diabetes (T2D) is a complex metabolic disease regulated by an interaction of genetic predisposition and environmental factors. To understand the genetic contribution in the development of diabetes, mice varying in their disease susceptibility were
Heja Aga, Heja Aga, Nicole Hallahan, Nicole Hallahan, Pascal Gottmann, Pascal Gottmann, Markus Jaehnert, Markus Jaehnert, Sophie Osburg, Sophie Osburg, Gunnar Schulze, Gunnar Schulze, Anne Kamitz, Anne Kamitz, Danny Arends, Gudrun Brockmann, Tanja Schallschmidt, Tanja Schallschmidt, Sandra Lebek, Sandra Lebek, Alexandra Chadt, Alexandra Chadt, Hadi Al-Hasani, Hadi Al-Hasani, Hans-Georg Joost, Hans-Georg Joost, Annette Schürmann, Annette Schürmann, Annette Schürmann, Heike Vogel, Heike Vogel, Heike Vogel   +31 more
doaj   +1 more source

Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology. [PDF]

PLoS ONE, 2014
The female lower genital tract is constantly exposed to microbial infection, some of which can ascend to and cause pathology such as hydrosalpinx in the upper genital tract, which can affect fertility.
Jianlin Chen, Hongbo Zhang, Zhou Zhou, Zhangsheng Yang, Yiling Ding, Zhiguang Zhou, Edward Zhong, Bernard Arulanandam, Joel Baseman, Guangming Zhong   +9 more
doaj   +1 more source

QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains [PDF]

, 2009
Peer reviewedPublisher ...
Blizard, David A, Koide, Tsuyoshi, Kuriki, Satoshi, Lionikas, Arimantas, Nishi, Akinori, Sakaguchi, Takayuki, Umemori, Juzoh   +6 more
core   +3 more sources

Technetium-99m pyrophosphate uptake in spontaneously occurring perimyocardial lesions in an inbred strain of DBA/2 mice.

Japanese Circulation Journal, 1982
The spontaneous occurrence of perimyocardial calcification localized in the right ventricle has been reported in an inbred strain of DBA/2 mice. In this paper we examined the correlation between the myocardial uptake ratio of technetium-99m pyrophosphate (99mTc-PYP) and pathological findings in these mice ranging in age from one to 12 months and became
A, Yoshida, A, Matsumori, C, Kawai, K, Torizuka   +3 more
openaire   +3 more sources

Homocysteine: Canary in the Coal Mine or Hidden Threat? A Biochemical Study on the Role of Plasma Thiols

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
The figure illustrates how high plasma glutathione levels can promote the dethiolation of homocysteinylated proteins, leading to the release of homocysteine. The freed homocysteine is then either excreted through the kidneys or further processed via cellular metabolism, supporting homocysteine clearance and metabolic balance.
Daniela Giustarini, Sante Colella, Isabella Dalle‐Donne, Ranieri Rossi   +3 more
wiley   +1 more source

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

Bone Research
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally acquired and associated with RA susceptibility.
Hongzhen Chen, Xuekun Fu, Xiaohao Wu, Junyi Zhao, Fang Qiu, Zhenghong Wang, Zhuqian Wang, Xinxin Chen, Duoli Xie, Jie Huang, Junyu Fan, Xu Yang, Yi Song, Jie Li, Dongyi He, Guozhi Xiao, Aiping Lu, Chao Liang   +17 more
doaj   +1 more source