Results 91 to 100 of about 135,853 (215)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2

Journal of Lipid Research, 2000
Dietary cholesterol is known to raise total and low density lipoprotein cholesterol concentrations in humans and experimental animals, but the response among individuals varies greatly.
Aram Mouzeyan, Junghee Choi, Hooman Allayee, Xuping Wang, Janet Sinsheimer, Jack Phan, Lawrence W. Castellani, Karen Reue, Aldons J. Lusis, Richard C. Davis   +9 more
doaj   +1 more source

Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]

, 2004
Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S., Simon, Michelle, Kumar, Saumya, Fernandes, Vitor E., Sylvius, Nicolas, Mallon, Ann-Marie, Denny, Paul, Andrew, Peter W.   +7 more
core   +5 more sources

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?

Frontiers in Psychiatry
Under conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed, Cheryl Reed, Tamara J. Phillips, Tamara J. Phillips, Tamara J. Phillips   +4 more
doaj   +1 more source

Inherent and antigen-induced airway hyperreactivity in NC mice

Allergology International, 1999
In order to clarify the airway physiology of NC mice, the following experiments were carried out. To investigate inherent airway reactivity, we compared tracheal reactivity to various chemical mediators in NC, BALB/c, C57BL/6 and A/J mice in vitro.
Tetsuto Kobayashi, Toru Miura, Tomoko Haba, Miyuki Sato, Masao Takei, Isao Serizawa   +5 more
doaj   +1 more source

In Silico Approaches and the Role of Ontologies in Aging Research [PDF]

, 2013
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke, Börries, Melanie, de Grey, Aubrey, Fuellen, Georg, Hahn, Udo, Hiller, Thomas, Hoeflich, Andreas, Jansen, Ludger, Janssens, Georges E., Kaleta, Christoph, Meinema, Anne C., Others, Schofield, Paul N., Schäuble, Sascha, Smith, Barry   +14 more
core  

Chromatin variation associated with liver metabolism is mediated by transposable elements [PDF]

, 2016
Additional file 1: Supplementary methods. Figure S1. Phenotypic diversity in different inbred strains. Figure S2. Chromatin variability across inbred strains of mice. Figure S3. Association between chromatin variation and SNPs. Figure S4.
Aldons J. Lusis, Amy Leung, Brian W. Parks, Candi Trac, Dustin E. Schones, Juan Du, Michael Lee, Rama Natarajan   +7 more
core   +2 more sources

Subclass III SnRK2 Kinases Coordinate Starch and Storage Protein Synthesis During Maize Kernel Development

Plant Biotechnology Journal, EarlyView.
ABSTRACT Enhancing both starch and protein accumulation is a key strategy for improving maize yield and quality. Achieving this goal requires an in‐depth understanding of the regulatory mechanisms that integrate these pathways. Here, we demonstrate that functionally redundant subclass III SNF1‐related protein kinase 2s (SnRK2s) act as central ...
Yayun Wang, Tiandan Long, Changqing Mao, Shan Feng, Qiang Liao, Yufeng Hu, Junjie Zhang, Hanmei Liu, Yinghong Liu, Xiujun Fan, Lei Gao, Canmei Cun, Binjie Xu, Daqiu Zhao, Jing Wang, Yubi Huang, Yangping Li   +16 more
wiley   +1 more source

Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.

PLoS ONE, 2018
Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and the tools to assess these vaccines.
Raju Sunagar, Sudeep Kumar, Prachi Namjoshi, Sarah J Rosa, Karsten R O Hazlett, Edmund J Gosselin   +5 more
doaj   +1 more source