Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]
, 2004 Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S. +7 more
core +5 more sources
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]
, 2016 We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta +8 more
core +3 more sources
QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains [PDF]
, 2009 Peer reviewedPublisher ...
Blizard, David A +6 more
core +3 more sources
Ethanol Teratogenesis in Five Inbred Strains of Mice [PDF]
Alcoholism: Clinical and Experimental Research, 2009 Background: Previous studies have demonstrated individual differences in susceptibility to the detrimental effects of prenatal ethanol exposure. Many factors, including genetic differences, have been shown to play a role in susceptibility and resistance, but few studies have investigated the range of genetic variation in rodent models.Methods: We ...
Hali Broncucia +4 more
openaire +3 more sources
Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]
, 2002 Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R. +4 more
core +2 more sources
Lifespan modulation in mice and the confounding effects of genetic background [PDF]
, 2014 We are currently in the midst of a revolution in ageing research, with several dietary, genetic and pharmacological interventions now known to modulate ageing in model organisms.
Mulvey, Lorna +2 more
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Experimentation with Animals: A Key Aspect of the 3Rs. The Genetic Quality [PDF]
, 2019 The genetic quality of laboratory animals is essential for reproducibility of scientific research. Working with animals of certifiedgenetic quality is still a pending issue in Argentina due to the lack of routine genetic controls, of information on the ...
Castillo, Nadia Sabiela +4 more
core +1 more source
Strain variation in spermatozoal glycosidases in inbred mice
Genetical Research, 1978 SUMMARYTen glycosidases were measured in suspensions of spermatozoa from the vasa deferentia of two inbred mouse strains and their intercrosses. Eight of these glycosidases were associated with the sperm cells and all of these showed genetical variation between the strains except α-l-fucosidase with optimal activity at pH 5·4.
Self, S J, Winchester, B G, Archer, J R
openaire +3 more sources
Genetic regulation of mouse liver metabolite levels. [PDF]
, 2014 We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J +11 more
core +1 more source
Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. [PDF]
, 2013 It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are due to both genetic and environmental factors. Animal studies provide important translational models for elucidating specific genetic or environmental factors ...
Ashwood, P +5 more
core +2 more sources