Results 21 to 30 of about 259,574 (259)

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site

Heredity, 2020
For over a century, inbred mice have been used in many areas of genetics research to gain insight into the genetic variation underlying traits of interest. The generalizability of any genetic research study in inbred mice is dependent upon all individual
Jobran Chebib, Benjamin C. Jackson, Eugenio López-Cortegano, D. Tautz, P. Keightley   +4 more
semanticscholar   +1 more source

Sperm morphology in two house mouse subspecies: do wild-derived strains and wild mice tell the same story? [PDF]

PLoS ONE, 2014
Being subject to intense post-copulatory selection, sperm size is a principal determining component of male fitness. Although previous studies have presented comparative sperm size data at higher taxonomic levels, information on the evolution of sperm ...
Jana Albrechtová, Tomáš Albrecht, Ludovít Ďureje, Vincent A Pallazola, Jaroslav Piálek   +4 more
doaj   +1 more source

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS

Медицинская иммунология, 2014
. The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium ...
D. V. Balunets, L. N. Nesterenko, Yu. S. Romanova, Yu. S. Alyapkina, N. I. Kolkova, A. S. Apt   +5 more
doaj   +3 more sources

Rift Valley Fever Virus Is Lethal in Different Inbred Mouse Strains Independent of Sex

Frontiers in Microbiology, 2020
Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting humans and livestock in Africa and the Arabian Peninsula. The majority of human cases are mild and self-limiting; however, severe cases can result in hepatitis, encephalitis, or hemorrhagic
Haley N. Cartwright, Haley N. Cartwright, Dominique J. Barbeau, Dominique J. Barbeau, Anita K. McElroy, Anita K. McElroy   +5 more
doaj   +1 more source

Susceptibility Analysis in Several Mouse Strains Reveals Robust T-Cell Responses After Mycoplasma pneumoniae Infection in DBA/2 Mice

Frontiers in Cellular and Infection Microbiology, 2021
Mycoplasma pneumoniae (Mp) is a highly contagious respiratory pathogen responsible for human community-acquired pneumonia. The number of antibiotic-resistant Mp strains is increasing; therefore, to develop novel therapeutics, it is crucial to precisely ...
Shigeyuki Tamiya, Shigeyuki Tamiya, Shigeyuki Tamiya, Eisuke Yoshikawa, Eisuke Yoshikawa, Eisuke Yoshikawa, Koichiro Suzuki, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +11 more
doaj   +1 more source

Analysis of structural variation among inbred mouse strains

BMC Genomics, 2023
Background ‘Long read’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic diseases.
Ahmed Arslan, Zhuoqing Fang, Meiyue Wang, Yalun Tan, Zhuanfen Cheng, Xinyu Chen, Yuan Guan, Laura J. Pisani, Boyoung Yoo, Gill Bejerano, Gary Peltz   +10 more
doaj   +1 more source

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. [PDF]

, 2016
The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL).
Allayee, Hooman, Crow, Amanda L, Eskin, Eleazar, Friedman, Rick A, Ge, Marshall, Lavinsky, Joel, Lusis, Aldons J, Myint, Anthony, Pan, Calvin, Salehi, Pezhman, Wang, Juemei   +10 more
core   +7 more sources

Different mice inbred strains humoral immune response against human prostate-specific antigen

Ukrainian Biochemical Journal, 2019
The aim of the study was an investigation of humoral immune response to prostate-specific antigen (PSA) of different mice inbred strains for further development of recommendations for appropriate immunization schemes for monoclonal antibodies (mcabs ...
O. Galkin, A. Komar, O. Besarab
semanticscholar   +1 more source

Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]

, 1975
The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E., Kristal, Dr. Mark B.   +1 more
core   +1 more source