Results 21 to 30 of about 145,801 (250)
Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains
Frontiers in Physiology, 2017 Changes in cardiorespiratory fitness in response to a standardized exercise training protocol differ substantially between individuals. Results from cross-sectional, twin, and family studies indicate genetics contribute to individual differences in both ...
Joshua J. Avila +2 more
doaj +1 more source
Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. [PDF]
PLoS ONE, 2010 Progressive sensorineural hearing loss is the most common form of acquired hearing impairment in the human population. It is also highly prevalent in inbred strains of mice, providing an experimental avenue to systematically map genetic risk factors and ...
Konrad Noben-Trauth +3 more
doaj +1 more source
Reprograming of proteasomal degradation by branched chain amino acid metabolism
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Using genetics and multi‐omics analyses in Caenorhabditis elegans, we identified adaptive regulation of the ubiquitin‐proteasome system (UPS) in response to defective branched chain amino acid (BCAA) metabolism. Worms with impaired BCAA metabolism show slower turnover of a GFP‐based proteasome substrate, which is suppressed by loss‐of‐function of the ...
Sonia Ravanelli +5 more
wiley +1 more source
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]
, 2016 We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta +8 more
core +7 more sources
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Across studies, metformin seems to prolong lifespan in nematodes fed a specific bacterial diet but not in mice and may have a larger effect if started early in life. Abstract There is growing interest in the use of metformin to extend lifespan and prevent the onset of age‐related disorders in non‐diabetic individuals.
Austin J. Parish, William R. Swindell
wiley +1 more source
An excess of gene expression divergence on the X chromosome in Drosophila embryos; implications for the faster-X hypothesis [PDF]
PLoS Genetics (2012)8(12):e1003200, 2012 The X chromosome is present as a single copy in the heterogametic sex, and this hemizygosity is expected to drive unusual patterns of evolution on the X relative to the autosomes. For example, the hemizgosity of the X may lead to a lower chromosomal effective population size compared to the autosomes suggesting that the X might be more strongly ...
arxiv +1 more source
Predicting Yield Performance of Parents in Plant Breeding: A Neural Collaborative Filtering Approach [PDF]
PLoS ONE 15(5): e0233382 (2020), 2020 Experimental corn hybrids are created in plant breeding programs by crossing two parents, so-called inbred and tester, together. Identification of best parent combinations for crossing is challenging since the total number of possible cross combinations of parents is large and it is impractical to test all possible cross combinations due to limited ...
arxiv +1 more source
Spontaneous Testicular Teratomas in an Inbred Strain of Mice [PDF]
Proceedings of the National Academy of Sciences, 1954 Descriptions of teratoid tumors of the mammalian testis, other than for man and ie horse, are ,are. In mice'oteratoma testis has not heretofore been reported. urthermore,.there are only a few descriptions of the ovarian counterpart of this 'pe of tumor in the mouse.", 2, 3, 4 In view of the paucity of information concerng teratomas in mice, their ...
Stevens, L C, Little, C C
openaire +3 more sources
High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]
, 2015 Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A +6 more
core +1 more source
Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism
Aging Cell, Volume 21, Issue 12, December 2022., 2022 The proposed mechanism of CR‐specific effects of SAAR on adipose metabolism. (1) Due to the lack of Cys in SAAR diets, it imposes both MR and CR. CR specifically results in decreased biosynthesis of the tripeptide glutathione. (2) Lower hepatic glutathione increases the abundance of the transcription factor Nrf2, which translocates to the nucleus and ...
Sailendra N. Nichenametla +17 more
wiley +1 more source