Results 101 to 110 of about 122,026 (216)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris. [PDF]

Nat Commun
Zhang Y, Zeng L, Huang X, Wang Y, Chen G, Moses M, Zou Y, Xiong S, Xue W, Dong Y, Tian Y, Guan M, Hu L, Yin Z, Zhou D, Huang X, Chen C.   +16 more
europepmc   +1 more source

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Advanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma   +8 more
wiley   +1 more source

The molybdate transport protein ModA regulates nitrate reductase activity to increase the intestinal colonization and extraintestinal dissemination of <i>Klebsiella pneumoniae</i> in the inflamed gut. [PDF]

Virulence
Xie J, Wang H, Ma R, Fan J, Quan Q, Zhang Z, Li M, Li B.   +7 more
europepmc   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

SanA is an inner membrane protein mediating <i>Salmonella</i> Typhimurium infection. [PDF]

Microbiol Spectr
Stypułkowska A, Kolenda R, Carolak E, Czajkowska J, Dutkiewicz A, Waszczuk W, Bińczyk W, Thurston TLM, Grzymajło K.   +8 more
europepmc   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Arginine utilization in <i>Acinetobacter baumannii</i> is essential for pneumonia pathogenesis and is regulated by virulence regulator GacA. [PDF]

Infect Immun
Devnath K, Pathak A, Bakht P, Pathania R.   +3 more
europepmc   +1 more source

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, EarlyView.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

Hypervesiculation Meets Sec-Targeting: Enhancing Heterologous Protein Loading in <i>Salmonella</i> Typhi Outer Membrane Vesicles for Delivery and Immune Response. [PDF]

Int J Mol Sci
Fuentes I, Parra F, Rojas D, Silva A, Nevermann J, Otero MC, Gil F, Calderón IL, Fuentes JA.   +8 more
europepmc   +1 more source