Results 91 to 100 of about 1,780,625 (304)
Development of the obese-hyperglycaemic syndrome in mice [PDF]
Diabetologia, 1968 Mice with the recessively inherited, obese-hyperglycaemic syndrome were studied at different stages of their development. Homozygous carriers of the syndrome already exhibited an excessive accumulation of fat resulting in overweight at an age of 26 days. A few days later the concentration of serum immunoreactive insulin was raised and then continuously
openaire +2 more sources
Meal pattern of pre-obese SP1 mice.
, 2014 Mean (A) daily intake, (B) meal size and (C) meal number for standard chow and (D) intake, (E) meal size and (F) meal number for high-fat diet for NTg (black bars) synphilin-1 mice (white bars) at the “pre-obese” time-point ...
Xueping Li (138564) +10 more
core +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Chitinase expression in parotid glands of non-obese diabetic mice
, 2012 OBJECTIVE: This investigation was a basal study that used a mouse model of xerostomia to identify protein biomarkers of xerostomia in saliva. We identified genes expressed differently in parotid glands from non-obese diabetic mice with diabetes and ...
Haga-Tsujimura, Maiko +3 more
core +1 more source
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
Physiological ReportsObesity is characterized by compartmentalized inflammation in metabolic tissues and risk of dysglycemia, which can be influenced by bacterial components and metabolites (i.e., postbiotics).
Angela M. Schmidt +6 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
, 1959 Determination of dilution of administered labeled acetate by endogenously produced acetate in two types of obese mice: goldthioglucose obese mice (regulatory obesity) and obese hyperglycemic mice (metabolic obesity) shows that this dilution is of the ...
Claire Zomzely, Jean Mayer
core +1 more source
Advanced Science, EarlyView.As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia +13 more
wiley +1 more source