Results 81 to 90 of about 1,780,625 (304)
Pathological changes and metabolome analysis of liver in obese mouse models [PDF]
Jichu yixue yu linchuangObjective To detect the pathological changes in obese mice liver and explore the effects of obesity on hepatic metabolism. Methods Obese mouse model was successfully constructed by consecutive 24 weeks of high fat diet (HFD), while control group was ...
DING Baofeng, WANG Xiaoshuang, WANG Fang, YU Jia
doaj +1 more source
Advanced Materials, EarlyView.Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye +11 more
wiley +1 more source
Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice
JCI Insight, 2022 Obesity-induced asthma responds poorly to all current pharmacological interventions, including steroids, suggesting that classic, eosinophilic inflammation is not a mechanism.
Gina N. Calco +4 more
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Genistein treatment increases bone mass in obese, hyperglycemic mice
, 2016 Richard M Michelin,1 Layla Al-Nakkash,2 Tom L Broderick,3 Jeffrey H Plochocki4 1Arizona College of Osteopathic Medicine, 2Department of Physiology, 3Laboratory of Diabetes and Exercise Metabolism, Department of Physiology, 4Department of Anatomy, Arizona
Al-Nakkash L +3 more
core
Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice
, 1998 This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had an increased islet blood flow compared with age-matched lean mice ...
Leif Jansson +2 more
core +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice
Asian Pacific Journal of Tropical Biomedicine, 2018 Objective: To evaluate the insulin sensitivity action of ferulic acid (FA) in skeletal muscle and hypothalamus of high-fat diet (HFD)-induced obese mice. Methods: Obese mouse model was induced by HFD (45 kcal% lard fat) for 16 weeks. After 8 weeks of HFD
Jarinyaporn Naowaboot +5 more
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Metabolic features of normal and obese mice.
, 2013 (A) Representative glucose tolerance curves at eight and 16 months of normal and obese mice. (B) The area under the curve (AUC) of glucose tolerance test was calculated for each animal using the trapezoidal rule. n = 10.
Marcelo Ezquer (356931) +8 more
core +1 more source
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
Essential role of Card11 in airway hyperresponsiveness in high-fat diet-induced obese mice
Experimental and Molecular MedicineA high-fat diet (HFD) can induce airway hyperresponsiveness (AHR) in obese mice, independent of allergic sensitization. This study aimed to identify the key molecules related to AHR in HFD-induced obese mice.
Hyun-Seung Lee +4 more
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