Results 101 to 110 of about 240,716 (309)
AI–Guided 4D Printing of Carnivorous Plants–Inspired Microneedles for Accelerated Wound Healing
Advanced Materials, EarlyView.This work presents an artificial intelligence (AI)‐guided 4D‐printed microneedle platform inspired by carnivorous plants for wound healing. A thermo‐responsive shape memory polymer enables body temperature–triggered self‐coiling for autonomous wound closure.
Hyun Lee +21 more
wiley +1 more source
Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice
Asian Pacific Journal of Tropical Biomedicine, 2018 Objective: To evaluate the insulin sensitivity action of ferulic acid (FA) in skeletal muscle and hypothalamus of high-fat diet (HFD)-induced obese mice. Methods: Obese mouse model was induced by HFD (45 kcal% lard fat) for 16 weeks. After 8 weeks of HFD
Jarinyaporn Naowaboot +5 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
High fat diet deviates PtC-specific B1 B cell phagocytosis in obese mice [PDF]
, 2014 Phagocytosis had been attributed predominantly to "professional" phagocytes such as macrophages, which play critical roles in adipose tissue inflammation.
Allaimo, Danielle +8 more
core +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Essential role of Card11 in airway hyperresponsiveness in high-fat diet-induced obese mice
Experimental and Molecular MedicineA high-fat diet (HFD) can induce airway hyperresponsiveness (AHR) in obese mice, independent of allergic sensitization. This study aimed to identify the key molecules related to AHR in HFD-induced obese mice.
Hyun-Seung Lee +4 more
doaj +1 more source
A Third Variable in Obesity: The Effects of Brown Adipose Tissue on Thermogenesis
, 1981 Approaches to weight management which consider only energy intake and/or expenditure do not consistently lead to favorable outcomes. A third variable, thermogenesis, must also be considered in a comprehensive understanding of obesity· Three types of ...
McMinn, Mark R.
core
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. [PDF]
, 2014 Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm.
Blazar, Bruce +18 more
core +1 more source
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Advanced Science, EarlyView.Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim +7 more
wiley +1 more source