Results 121 to 130 of about 1,780,625 (304)

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Insulin Sensitivity of Obese, Chemically-Induced Obese, and Nonobese Mice

, 1973
15 p.The hyperglycemia concurrent with obesity in mice has been found to be resistant to the administration of insulin. By using five different strains of mice, including a strain with induced obesity by means of goldthioglucose, comparison was made ...
Oom, Robert A.
core  

SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages

Advanced Science, EarlyView.
SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang   +8 more
wiley   +1 more source

Increased metabolic efficiency in obese mutant mice.

, 1985
Several different single gene mutations are known to cause similar diabetes-obesity syndromes in mice. Our studies with two mutations, obese (ob) and diabetes (db) have shown that each syndrome develops similarly.
Coleman, D L
core   +1 more source

Metabolic biomarkers recovered from urine and fecal extracts during influenza infection in lean and obese mice^a.

, 2014
aBolded and underlined urine and feces indicates that metabolite was significantly higher in obese mice, and metabolites in normal font were significantly lower in obese mice. UK: unknown metabolite. n = 8–9.
Jasmina Saric (50195), Patricia A. Sheridan (566752), Melinda A. Beck (564066), J. Justin Milner (566751), Tim Ebbels (566753), Jue Wang (58890)   +5 more
core   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Blood variables, atherosclerosis and gene expression in aorta of lean and obese mice.

, 2017
Blood variables, atherosclerosis and gene expression in aorta of lean and obese mice.
Maarten Vanhaverbeke (3697519), Benjamine Geeraert (187732), Maarten Hulsmans (181118), Dieuwke De Keyzer (187734), Stefan Janssens (390984), Paul Holvoet (122610)   +5 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

The mitigation of activity-based anorexia by obese adipose tissue transplant is abolished by neonatal AgRP neuron ablation

Translational Psychiatry
Anorexia nervosa (AN) is an eating disorder observed primarily in girls and women, and is characterized by a low body weight, hypophagia, and hyperactivity.
Dongmin J. Yoon, Jie Zhang, Rizaldy C. Zapata, Martina Ulivieri, Avraham M. Libster, Matthew S. McMurray, Olivia Osborn, Stephanie C. Dulawa   +7 more
doaj   +1 more source