Results 191 to 200 of about 241,974 (292)

The role of immune cells-mediated memory in weight cycling, glucose disorders and insulin resistance. [PDF]

Front Immunol
Chen Y, Zhou D, Wang L, Sun L, Yin Y, Liu G, Zi C.   +6 more
europepmc   +1 more source

Cytosolic lipid trafficking proteins STARD4 and STARD5 modulate hepatic neutral lipid metabolism: implications for diabetic dyslipidaemia and steatosis [PDF]

, 2015
Dolan, Sharron, Graham, Annette, Soffientini, Ugo   +2 more
core   +1 more source

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice. [PDF]

Mol Med
Aslam MR, Bilal M, Nawaz A, Kado T, Abe S, Phuong NQ, Memoona, Khalid S, Anh LD, Nishimura A, Watanabe Y, Igarashi Y, Iqbal N, Yokoyama M, Onogi Y, Hirabayashi K, Miwa H, Era T, Matzuk MM, Yamamoto S, Ikuta K, Usui I, Kobayashi K, Satake T, Kato M, Fujisaka S, Tobe K.   +26 more
europepmc   +1 more source

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Myostatin in Obesity: A Molecular Link Between Metabolic Dysfunction and Musculotendinous Remodeling. [PDF]

Int J Mol Sci
Cesanelli L, Minderis P, Fokin A, Ratkevicius A, Satkunskiene D, Degens H.   +5 more
europepmc   +1 more source

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

Bariatric Surgery Alters Oral Microbiome: Evidence From Obese Patients and a Mouse Model. [PDF]

Int Dent J
Shahin A, Schyr R, Sharon E, Coppenhagen-Glazer S, Koren O, Elazary R, Ben-Zvi D, Raveh D, Hazan R, Houri-Haddad Y.   +9 more
europepmc   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Effects of maternal BMI on early pregnancy endocrine-metabolic function and offspring development: Evidence from a retrospective cohort and animal model. [PDF]

PLoS One
Shen W, Niu A, Zhang Q, Deng J, Xu X, Ma X, Zhao H, Lou Y.   +7 more
europepmc   +1 more source