Effect of acute ozone exposure on the lung metabolomes of obese and lean mice. [PDF]
PLoS ONE, 2017 Pulmonary responses to the air pollutant, ozone, are increased in obesity. Both obesity and ozone cause changes in systemic metabolism. Consequently, we examined the impact of ozone on the lung metabolomes of obese and lean mice.
Joel Andrew Mathews +6 more
doaj +1 more source
Nutrition & Metabolism, 2012 Background Obesity associates with low-grade inflammation and adipose tissue remodeling. Using sensitive high-throughput protein arrays we here investigated adipose tissue cytokine and angiogenesis-related protein profiles from obese and lean mice, and ...
Kurki Eveliina +4 more
doaj +1 more source
High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]
, 2015 The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Armando, Aaron M +6 more
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Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. [PDF]
PLoS ONE, 2014 During the recent H1N1 outbreak, obese patients had worsened lung injury and increased mortality. We used a murine model of influenza A pneumonia to test the hypothesis that leptin receptor deficiency might explain the enhanced mortality in obese ...
Kathryn A Radigan +11 more
doaj +1 more source
Frontiers in Nutrition, 2022 Exercise is considered as a favorable measure to prevent and treat childhood obesity. However, the underlying mechanisms of exercise-induced beneficial effects and the difference between obese and non-obese individuals are largely unclear.
Dongxue Wang +11 more
doaj +1 more source
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]
, 2015 A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M +28 more
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Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. [PDF]
, 2014 Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm.
Blazar, Bruce +18 more
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WAT-free mice: diabetes without obesity [PDF]
Genes & Development, 1998 Two papers appearing in this issue report the generation of transgenic mice largely devoid of white adipose tissue (WAT). In both cases the resulting mice display anatomical and physiological properties very similar to human patients suffering from generalized lipodystrophy.
openaire +2 more sources
Is fat the sixth taste primary? Evidence and implications [PDF]
, 2015 Explores our tongue\u27s ability to detect fat as a distinct taste similar to our ability to sense sweet, sour, bitter, acid and savory. Abstract Taste is the chemical sense responsible for the detection of non-volatile chemicals in potential foods. For
Andrew Costanzo, Russell Keast
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Effect of short-term probiotic Enterococcus faecium SF68 dietary supplementation in overweight and obese cats without comorbidities [PDF]
, 2016 Obesity in cats is associated with metabolic abnormalities and increased susceptibility to diseases such as diabetes mellitus. Studies in mouse models and human beings have shown that probiotics can reduce food intake, promote weight loss and improve ...
Fascetti, A J +3 more
core +1 more source