Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]
, 2010 Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Brockington, M +7 more
core +32 more sources
Molecules, 2022 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that might lead to very serious consequences. Notably, mental status change, brain confusion, and smell and taste disorders along with neurological ...
Simona Dedoni +6 more
doaj +1 more source
Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment. [PDF]
PLoS ONE, 2013 BACKGROUND: T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development and progression. Our previous study in vitro and in nude mice suggested a promotion role of Tiam1 on invasion and metastasis of colorectal cancer (CRC).
Li-Na Yu +7 more
doaj +1 more source
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Frontiers in Bioscience-Landmark, 2023 Neurodegenerative diseases (NDs) are some of the most important health challenges modern medicine and advanced societies face. Indeed, the number of patients affected by one of these illnesses will increase in the following years at the same rate that ...
Alba Marín-Moreno +4 more
doaj +1 more source
Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 () Transgenic Mice [PDF]
Intestinal Research, 2015 Background/AimsCaudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach.
Hirotsugu Sakamoto +7 more
doaj +1 more source
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Takeo Ohsugi, Toshio Kumasaka
doaj +1 more source
Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo. [PDF]
PLoS ONE, 2018 Calcium imaging is commonly used to measure the neural activity of large groups of neurons in mice. Genetically encoded calcium indicators (GECIs) can be delivered for this purpose using non-invasive genetic methods.
Hod Dana +8 more
doaj +1 more source
Journal of Diabetes Research, 2021 To rigorously explore the role of omega-3 polyunsaturated fatty acids (PUFA) in the treatment of diabetic peripheral neuropathy (DPN), we have created a transgenic mouse utilizing a Cre-lox promoter to control overexpression of human 15-lipoxygenase-1 ...
Lawrence Coppey +5 more
doaj +1 more source
Stem Cell Reports, 2014 The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency.
Maria Luigia De Bonis +2 more
doaj +1 more source
Approaches for timeline reductions in pathogenesis studies using genetically modified mice
Microbiology Spectrum, 2023 Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
doaj +1 more source