Results 191 to 200 of about 6,887,725 (399)

CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development [PDF]

, 2020
Rédouane Aherrahrou, Alexandra Kulle, Natália Alenina, Ralf Werner, Simeon Vens-Cappell, Michael Bäder, Heribert Schunkert, Jeanette Erdmann, Zouhair Aherrahrou   +8 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Sex differences in endurance exercise capacity and skeletal muscle lipid metabolism in mice

, 2022
Lola Holcomb, Patrick Rowe, Caitlin O’Neill, Elizabeth DeWitt, Stephen C. Kolwicz   +4 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

, 2013
Liset Westera, Julia Drylewicz, Ineke den Braber, Tendai Mugwagwa, I. Maas, Lydia M. Kwast, Thomas J. H. Volman, Elise H. R. van de Weg-Schrijver, István Bartha, G. Th. Spierenburg, Koos Gaiser, Mariëtte T. Ackermans, Becca Asquith, Rob J. de Boer, Kiki Tesselaar, José A. M. Borghans   +15 more
openalex   +2 more sources

Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming

, 2022
Ruo‐Ran Wang, Xinyuan Qiu, Ran Pan, Hongxing Fu, Ziyin Zhang, Qintao Wang, Haide Chen, Qingqian Wu, Xiaowen Pan, Yanping Zhou, Peng‐Fei Shan, Shusen Wang, Guoji Guo, Min Zheng, Lingyun Zhu, Zhuo‐Xian Meng   +15 more
openalex   +2 more sources

Sirt3 Promotes Chondrogenesis, Chondrocyte Mitochondrial Respiration and the Development of High-Fat Diet-Induced Osteoarthritis in Mice [PDF]

, 2020
Shouan Zhu, Elise L. Donovan, Dawid Mąkosa, Padmaja Mehta-D’souza, Anita Jopkiewicz, Albert Batushansky, Dominic Cortassa, Aaron D. Simmons, Erika Barboza Prado Lopes, Michael Kinter, Timothy M. Griffin   +10 more
openalex   +1 more source

Analysis of the Correlation Between English Language Proficiency and the Professional Readiness of Students in Teacher Education Study Programs in Entering the Workforce

Jurnal Inovasi Pendidikan dan Sains
This study aims to analyze the correlation between English language proficiency and the professional readiness of students in teacher education study programs for entering the workforce. Students in teacher education study programs in Indonesia generally
Mella Narolita, Sri Rahayu
doaj  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source