Results 11 to 20 of about 209,966 (301)

Amphiphilic Block Copolymers: Their Structures, and Self-Assembly to Polymeric Micelles and Polymersomes as Drug Delivery Vehicles

Polymers, 2022
Self-assembly of amphiphilic block copolymers display a multiplicity of nanoscale periodic patterns proposed as a dominant tool for the ‘bottom-up’ fabrication of nanomaterials with different levels of ordering.
K. Kuperkar, Dhruvi Patel, L. Atanase, P. Bahadur   +3 more
semanticscholar   +1 more source

Polymeric Micelles for the Delivery of Poorly Soluble Drugs: from Nanoformulation to Clinical Approval

Advanced Drug Delivery Reviews, 2020
Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules with high potency and significant toxicity were encapsulated in polymeric ...
Duhyeong Hwang, Jacob D. Ramsey, A. Kabanov   +2 more
semanticscholar   +1 more source

Zwitterionic Micelles Efficiently Deliver Oral Insulin Without Opening Tight Junctions

Nature Nanotechnology, 2020
Oral delivery of protein drugs is considered a life-changing solution for patients who require regular needle injections. However, clinical translation of oral protein formulations has been hampered by inefficient penetration of drugs through the ...
Xiangfei Han, Yang Lu, Jinbing Xie, Ershuai Zhang, Hui Zhu, Hong Du, Ke Wang, Boyi Song, Chengbiao Yang, Yuanjie Shi, Zhiqiang Cao   +10 more
semanticscholar   +1 more source

Electron-Accepting Micelles Deplete Reduced Nicotinamide Adenine Dinucleotide Phosphate and Impair Two Antioxidant Cascades for Ferroptosis-Induced Tumor Eradication.

ACS Nano, 2020
Ferroptotic antitumor therapy has been compromised by various intracellular antioxidants, particularly glutathione and thioredoxin. Both are cofactors of glutathione peroxide 4 (GPX4) that act against oxidative stress via catalyzing the reduction of ...
Xuliang Guo, Fang Liu, Jian Deng, Peipei Dai, Yan Qin, Zhi Li, Bingbing Wang, Aiping Fan, Z. Wang, Yanjun Zhao   +9 more
semanticscholar   +1 more source

Self-assembly of multi-component fluorescent molecular logic gates in micelles [PDF]

, 2016
A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and
Magri, David C., Costa, Paola F. da, Paterson, Kyle A.   +2 more
core   +1 more source

Unfolding and refolding of cytochrome c driven by the interaction with lipid micelles [PDF]

, 2000
Binding of native cyt c to L-PG micelles leads to a partially unfolded conformation of cyt c. This micelle-bound state has no stable tertiary structure, but remains as -helical as native cyt c in solution.
Sanghera, Narinder, Pinheiro, Teresa J. T.   +1 more
core   +1 more source

Grafted block complex coacervate core micelles and their effect on protein adsorption on silica and polystyrene [PDF]

, 2010
peer reviewedWe have studied the formation and the stability of grafted block complex coacervate core micelles (C3Ms) in solution and the influence of grafted block C3M coatings on the adsorption of the proteins beta-lactoglobulin, bovine serum albumin ...
Arie de Keizer, Cohen Stuart, Martien A., Brzozowska, Agata M., Norde, Willem, Christophe Detrembleur, Detrembleur, Christophe, Cohen Stuart, M.A., Agata M. Brzozowska, Willem Norde, de Keizer, Arie, Keizer, A., de, Stuart, Martien Cohen, Norde, W., Brzozowska, A.M., Detrembleur, C., Martien A. Cohen Stuart, de Keizer, A.   +16 more
core   +1 more source

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia [PDF]

, 2012
This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH), based on Pluronic® block copolymers, by a new microfluidic approach.
Carugo, D, Zhang, Xunli, Nastruzzi, C, Capretto, Lorenzo, Hill, M, Hill, Martyn, Gambari, Roberto, Capretto, L, Zhang, X, Mazzitelli, S, Brognara, E, Nastruzzi, Claudio, Brognara, Eleonora, Carugo, Dario, Gambari, R, Lampronti, I, Mazzitelli, Stefania, Lampronti, Ilaria   +17 more
core   +1 more source

Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation [PDF]

, 2014
Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each ...
Wilson, Neil R., Dyson, M.A., Schiller, Tara L, Dove, Andrew P., Schiller, T.L., Schiller, Tara, Dyson, M Adam, Sanchez, A.M., Sun, Liang, O'Reilly, R.K., Wilson, Neil R, Pitto-Barry, Anaïs, Schiller, Tara L., Kirby, Nigel, Sloan, Jeremy, Dyson, Mark Adam, Sun, L., O'Reilly, Rachel K; id_orcid, O'Reilly, Rachel K, Sloan, J., O’Reilly, Rachel K., Dove, Andrew P, Sanchez, Ana M., Kirby, N., Wilson, N.R., Dove, A.P., Sanchez, Ana M   +26 more
core   +1 more source

Formation and structure of ionomer complexes from grafted polyelectrolytes [PDF]

, 2011
We discuss the structure and formation of Ionomer Complexes formed upon mixing a grafted block copolymer (poly(acrylic acid)-b-poly(acrylate methoxy poly(ethylene oxide)), PAA21-b-PAPEO14) with a linear polyelectrolyte (poly(N-methyl 2-vinyl pyridinium ...
Arie de Keizer, Keesman, K.J., Agata M. Brzozowska, Leermakers, F.A.M., Keizer, A., de, Brzozowska, A.M., Karel J. Keesman, Frans A. M. Leermakers, de Keizer, A.   +8 more
core   +1 more source