Results 41 to 50 of about 125,431 (305)

Preparation and In Vitro and In Vivo Antitumor Effects of VEGF Targeting Micelles

Technology in Cancer Research & Treatment, 2020
Background: Doxorubicin (DOX) has antitumor effects mediated by cell viability inhibition and by inducing cellular apoptosis. However, it has limited use in clinical applications due to various factors such as hydrophobicity, dose-dependent toxicity ...
Jing Chang MD, Zhe Yang BD, Junfeng Li MD, Yufen Jin MD, Yihang Gao MD, Yanwen Sun MD, Hainan Li MD, Ting Yu PhD   +7 more
doaj   +1 more source

Multi-Functional Drug Carrier Micelles With Anti-inflammatory Drug

Frontiers in Chemistry, 2019
The multi-functional micelles poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide-co-10 undecanoic acid)/CM-Dextran Fe3O4 (PNDU/CM-Dex Fe3O4) were poly (NIPAAm-co-DMAAm-co-UA) (PNDU) grafting hydrophilic CM-Dextran Fe3O4 which possess pH-dependent ...
Wei-Jie Wang, Wei-Jie Wang, Yin-Chou Huang, Chao-Ming Su, Tzong-Rong Ger   +4 more
doaj   +1 more source

MICELLIZATION OF CASEIN-DEXSTRAN STRUCTURES OBTAINED IN THE MAILLARD REACTION

Вестник Северо-Кавказского федерального университета, 2022
Micelles were prepared by the crosslinking copolymerization of casein and dextran in the Maillard reaction. Glycated proteins were identified using ft-IR spectrometry.
Roman Budkevich, Anastasiya Eremina, Elena Budkevich, Gennady Slyusarev   +3 more
doaj  

Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery

Drug Delivery, 2019
Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might ...
Mengshuang Li, Jie Lan, Xuefei Li, Meng Xin, Hui Wang, Fan Zhang, Xiaohong Lu, Zengfang Zhuang, Xianggen Wu   +8 more
doaj   +1 more source

Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells

Research in Pharmaceutical Sciences
Background and purpose: Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted drug delivery. In the present study, a polymeric micelle composed of folic acid (FA), heparin (HEP), dexamethasone (DEX), and (FA ...
Jaber Emami, Moloud Kazemi, Mina Mirian
doaj   +1 more source

Formation and structure of ionomer complexes from grafted polyelectrolytes [PDF]

, 2011
We discuss the structure and formation of Ionomer Complexes formed upon mixing a grafted block copolymer (poly(acrylic acid)-b-poly(acrylate methoxy poly(ethylene oxide)), PAA21-b-PAPEO14) with a linear polyelectrolyte (poly(N-methyl 2-vinyl pyridinium ...
Arie de Keizer, Keesman, K.J., Agata M. Brzozowska, Leermakers, F.A.M., Keizer, A., de, Brzozowska, A.M., Karel J. Keesman, Frans A. M. Leermakers   +7 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

pH-sensitive charge-conversion cinnamaldehyde polymeric prodrug micelles for effective targeted chemotherapy of osteosarcoma in vitro

Frontiers in Chemistry, 2023
Introduction: Chemotherapy is a common strategy for the treatment of osteosarcoma. However, its therapeutic efficacy is not ideal due to the low targeting, lowbioavailability, and high toxicity of chemotherapy drugs.
Jiapeng Deng, Jiapeng Deng, Su Liu, Su Liu, Guoqing Li, Guoqing Li, Yien Zheng, Yien Zheng, Weifei Zhang, Weifei Zhang, Jianjing Lin, Fei Yu, Fei Yu, Jian Weng, Jian Weng, Peng Liu, Peng Liu, Hui Zeng, Hui Zeng   +18 more
doaj   +1 more source

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions [PDF]

, 2010
Gene therapy is expected to open a new strategy for the treatment of refractory vascular diseases, so the development of appropriate gene vectors for vascular lesions is needed. To realize this requirement with a non-viral approach, cyclo(RGDfK) peptide (
Tetsuro Miyata, Makoto Oba, Yutaka Miura, Tsuyoshi Takato, Hiroyuki Koyama, Hideo Kagaya, Kazunori Kataoka, Takehiko Ishii   +7 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source