Results 31 to 40 of about 117,565 (253)

Free energy profiles for penetration of methane and water molecules into spherical sodium dodecyl sulfate micelles obtained using the thermodynamic integration method combined with molecular dynamics calculations [PDF]

, 2012
The free energy profiles, ΔG(r), for penetration of methane and water molecules into sodium dodecyl sulfate (SDS) micelles have been calculated as a function of distance r from the SDS micelle to the methane and water molecules, using the thermodynamic ...
K. Fujimoto, N. Yoshii, Yoshii, N., S. Okazaki, Fujimoto, K., Okazaki, S.   +5 more
core   +1 more source

Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery

Drug Delivery, 2019
Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might ...
Mengshuang Li, Jie Lan, Xuefei Li, Meng Xin, Hui Wang, Fan Zhang, Xiaohong Lu, Zengfang Zhuang, Xianggen Wu   +8 more
doaj   +1 more source

Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells

Research in Pharmaceutical Sciences
Background and purpose: Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted drug delivery. In the present study, a polymeric micelle composed of folic acid (FA), heparin (HEP), dexamethasone (DEX), and (FA ...
Jaber Emami, Moloud Kazemi, Mina Mirian
doaj   +1 more source

Encapsulation of docosahexaenoic acid (DHA) using self-assembling food-derived proteins for efficient biological functions

Food Science and Human Wellness, 2023
Docosahexaenoic acid (DHA; 22n-6) possesses multiple biological functions, including antioxidant activity and ameliorating hypertriglyceridemia. However, the application of DHA has been limited due to poor aqueous solubility and susceptible to oxidation.
Yumeng Liu, Kaixin Cao, Tong Li, Delun Mu, Naiqi Zhang, Ying Wang, Rina Wu, Junrui Wu   +7 more
doaj   +1 more source

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice [PDF]

Advanced science
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Li Y, Lin H, Yu S, Liao Y, Huang T, Xiao Z, Lu W.   +6 more
europepmc   +2 more sources

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions [PDF]

, 2010
Gene therapy is expected to open a new strategy for the treatment of refractory vascular diseases, so the development of appropriate gene vectors for vascular lesions is needed. To realize this requirement with a non-viral approach, cyclo(RGDfK) peptide (
Tetsuro Miyata, Makoto Oba, Yutaka Miura, Tsuyoshi Takato, Hiroyuki Koyama, Hideo Kagaya, Kazunori Kataoka, Takehiko Ishii   +7 more
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

pH-sensitive charge-conversion cinnamaldehyde polymeric prodrug micelles for effective targeted chemotherapy of osteosarcoma in vitro

Frontiers in Chemistry, 2023
Introduction: Chemotherapy is a common strategy for the treatment of osteosarcoma. However, its therapeutic efficacy is not ideal due to the low targeting, lowbioavailability, and high toxicity of chemotherapy drugs.
Jiapeng Deng, Jiapeng Deng, Su Liu, Su Liu, Guoqing Li, Guoqing Li, Yien Zheng, Yien Zheng, Weifei Zhang, Weifei Zhang, Jianjing Lin, Fei Yu, Fei Yu, Jian Weng, Jian Weng, Peng Liu, Peng Liu, Hui Zeng, Hui Zeng   +18 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source