Results 31 to 40 of about 125,431 (305)

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia [PDF]

, 2012
This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH), based on Pluronic® block copolymers, by a new microfluidic approach.
Carugo, D, Zhang, Xunli, Nastruzzi, C, Capretto, Lorenzo, Hill, M, Hill, Martyn, Gambari, Roberto, Capretto, L, Zhang, X, Mazzitelli, S, Brognara, E, Nastruzzi, Claudio, Brognara, Eleonora, Carugo, Dario, Gambari, R, Lampronti, I, Mazzitelli, Stefania, Lampronti, Ilaria, Carugo D., Hill M., Capretto L., Zhang X.   +21 more
core   +1 more source

Grafted block complex coacervate core micelles and their effect on protein adsorption on silica and polystyrene [PDF]

, 2010
peer reviewedWe have studied the formation and the stability of grafted block complex coacervate core micelles (C3Ms) in solution and the influence of grafted block C3M coatings on the adsorption of the proteins beta-lactoglobulin, bovine serum albumin ...
Arie de Keizer, Cohen Stuart, Martien A., Brzozowska, Agata M., Norde, Willem, Christophe Detrembleur, Detrembleur, Christophe, Cohen Stuart, M.A., Agata M. Brzozowska, Willem Norde, de Keizer, Arie, Keizer, A., de, Stuart, Martien Cohen, Norde, W., Brzozowska, A.M., Detrembleur, C., Martien A. Cohen Stuart   +15 more
core   +2 more sources

Polyelectrolyte complex micelles by self-assembly of polypeptide-based triblock copolymer for doxorubicin delivery

Asian Journal of Pharmaceutical Sciences, 2014
Polyelectrolyte complex micelles were prepared by self-assembly of polypeptide-based triblock copolymer as a new drug carrier for cancer chemotherapy. The triblock copolymer, poly(l-aspartic acid)-b-poly(ethylene glycol)-b-poly(l-aspartic acid) (PLD-b ...
Jeong Hwan Kim, Thiruganesh Ramasamy, Tuan Hiep Tran, Ju Yeon Choi, Hyuk Jun Cho, Chul Soon Yong, Jong Oh Kim   +6 more
doaj   +1 more source

Poly(ethylene glycol)-sheddable reduction-sensitive polyurethane micelles for triggered intracellular drug delivery for osteosarcoma treatment

Journal of Orthopaedic Translation, 2020
Background: The survival rate of osteosarcoma therapy still lags behind overall cancer therapies due to the intrinsic or acquired drug resistance.
Zhengjie Yang, Qianping Guo, Yan Cai, Xuesong Zhu, Caihong Zhu, Yuling Li, Bin Li   +6 more
doaj   +1 more source

CKAP4 Antibody-Conjugated Si Quantum Dot Micelles for Targeted Imaging of Lung Cancer

Nanoscale Research Letters, 2021
At present, various fluorescent nanomaterials have been designed and synthesized as optical contrast agents for surgical navigation. However, there have been no reports on the preparation of fluorescent contrast agents for lung cancer surgery navigation ...
Xin Huang, Qian Chen, Xin Li, Chenyu Lin, Kun Wang, Cici Luo, Wenjun Le, Xiaodong Pi, Zhongmin Liu, Bingdi Chen   +9 more
doaj   +1 more source

Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization

Pharmaceutics, 2021
Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and d-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability of a poorly soluble drug, ebastine (EBT)
Nayyer Islam, Muhammad Irfan, Salah-Ud-Din Khan, Haroon Khalid Syed, Muhammad Shahid Iqbal, Ikram Ullah Khan, Amina Mahdy, Mohamed Raafat, Mohammad Akbar Hossain, Sana Inam, Rabia Munir, Memoona Ishtiaq   +11 more
doaj   +1 more source

Ultra-High to Ultra-Low Drug Loaded Micelles: Probing Host-Guest Interactions by Fluorescence Spectroscopy [PDF]

, 2019
Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug loaded polymer micelles.
Michael M, Lübtow, Henning, Marciniak, Alexander, Schmiedel, Markus, Roos, Christoph, Lambert, Robert, Luxenhofer   +5 more
core   +1 more source

Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo

Drug Delivery, 2018
Polyethylene glycol (PEG)-based block copolymer micelles and hyaluronic acid (HA)-based grafted copolymer micelles have been widely investigated in chemotherapy.
Jinling Wang, Ying Li, Lifang Wang, Xiaohui Wang, Pengfei Tu   +4 more
doaj   +1 more source

Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin

Pharmaceutical Sciences, 2016
Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a fast-acting blood active in treating the acute attack of malaria. Methods: Artemisinin was encapsulated within mPEG-PCL micelles
Hamid Reza Kheiri Manjili 1, Hojjat Malvandi 3, Mir-Sajjad Mosavi 1, Hossein Danafar 2,3 *
doaj   +1 more source

Encapsulation of docosahexaenoic acid (DHA) using self-assembling food-derived proteins for efficient biological functions

Food Science and Human Wellness, 2023
Docosahexaenoic acid (DHA; 22n-6) possesses multiple biological functions, including antioxidant activity and ameliorating hypertriglyceridemia. However, the application of DHA has been limited due to poor aqueous solubility and susceptible to oxidation.
Yumeng Liu, Kaixin Cao, Tong Li, Delun Mu, Naiqi Zhang, Ying Wang, Rina Wu, Junrui Wu   +7 more
doaj   +1 more source