Results 141 to 150 of about 1,382,076 (243)

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats

Drug Design, Development and Therapy
Cong Xie,1,2,* Tongshu Guan,1,2,* Jin Huang,1,2 Jiayu Chen,1,2 Yilei Li,1,2 Ping Zheng1,2 1Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Pharmacy, Nanfang ...
Xie C, Guan T, Huang J, Chen J, Li Y, Zheng P   +5 more
doaj  

Pharmacokinetics and aqueous humor penetration of levofloxacin 1.5% and moxifloxacin 0.5% in patients undergoing cataract surgery

Clinical Ophthalmology, 2016
Frank A Bucci Jr, Ines Teuma Nguimfack, Angel T Fluet Bucci Laser Vision Institute, Wilkes-Barre, PA, USA Purpose: The objective of this study was to compare the pharmacokinetics of levofloxacin 1.5% and moxifloxacin hydrochloride 0.5% ophthalmic ...
Bucci Jr FA, Nguimfack IT, Fluet AT
doaj  

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil, Norma A Valdez‐Cruz, Sara Restrepo‐Pineda, Nuria Sánchez‐Puig, Rafael Vázquez‐Duhalt, Rubén D Cadena‐Nava, Néstor O Pérez, Mauricio A Trujillo‐Roldán   +7 more
wiley   +1 more source

Molecular Imaging and Pharmacokinetic Analysis of Carbon-11 Labeled Antisense Oligonucleotide LY2181308 in Cancer Patients

Theranostics, 2011
Antisense oligonucleotides (ASOs) have potential as anti-cancer agents by specifically modulating genes involved in tumorigenesis. However, little is known about ASO biodistribution and tissue pharmacokinetics (PKs) in humans, including whether ...
Azeem Saleem, Julian C. Matthews, Malcolm Ranson, Sophie Callies, Valérie André, Michael Lahn, Claire Dickinson, Christian Prenant, Gavin Brown, Adam McMahon, Denis C. Talbot, Terry Jones, Patricia M. Price
doaj  

Posterior tibial slope is linearly related to anteroposterior shift of the tibiofemoral contact mechanics: A biomechanical study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To investigate the changes in tibiofemoral contact mechanics following an infra‐tubercle slope‐modifying osteotomy. Methods An infra‐tubercle slope‐modifying osteotomy was performed on eight fresh‐frozen cadaveric knees and fixed with an external fixator, which allowed for accurate slope adjustments from 15° to 0° in 5° increments. The
Christian Peez, Lucas K. Palma Kries, Arian Grose‐Allermann, Lara Leibrandt, Adrian Deichsel, Thorben Briese, Klemens Horst, Elmar Herbst, Christoph Kittl   +8 more
wiley   +1 more source

PK-Informed Microphysiological Systems: From Dynamic Dosing to Quantitative In Vitro-In Vivo Translation. [PDF]

Pharmaceutics
Kang SJ, Bong S, Jo MJ, Lee JM, Yoon MS, Park S, Lee Y, Shin Y, Lee HJ, Park CW, Shin DH.   +10 more
europepmc   +1 more source

Is DNA metabarcoding an option for formaldehyde‐preserved zooplankton time series?

Limnology and Oceanography: Methods, EarlyView.
Abstract The recovery of amplifiable DNA from formaldehyde‐fixed (FF) zooplankton samples has long been considered problematic, but advances in degraded‐DNA retrieval have renewed interest in FF samples. To access the information stored in long‐term zooplankton time series, we evaluated methods for extracting amplifiable DNA from community samples ...
Aitor Albaina, Anders Lanzén, Irati Miguel, Fernando Rendo, María Santos   +4 more
wiley   +1 more source

Dynamic Performance Enhancement of a High‐Agility Hypersonic Mechanical System via a Learning‐Augmented Robust Control Architecture

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT The design of control systems for high‐agility mechanical systems operating in extreme environments is a significant challenge in nonlinear dynamics. This paper addresses the complex dynamic control problem of a hypersonic interceptor, modeled as a multi‐input multi‐output (MIMO) mechanical system characterized by strong aerodynamic cross ...
Mohammad Mahdi Soori, Seyed Hossein Sadati   +1 more
wiley   +1 more source

Actively engaging multi-level stakeholders in cancer screening and cancer-related studies: a scoping review. [PDF]

Res Involv Engagem
McKinney G, Mikkelsen PA, Bøje RB, Tatari CR, Stenholt L, Larsen MB, Kirkegaard P.   +6 more
europepmc   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source