Results 161 to 170 of about 1,382,076 (243)

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

ESBL-Producing <i>Klebsiella pneumoniae</i> Bacteraemia with Renal Micro-Abscesses Treated with Cefepime-Enmetazobactam in a Neutropenic Allogeneic Transplant Recipient. [PDF]

Pathogens
Tascini C, Montanari L, Patriarca F, Bulfoni M, Fanin R, Giuliano S, Angelini J, Gaibani P.   +7 more
europepmc   +1 more source

Rise of the south: How Arab‐led maritime trade transformed China, 671–1371 CE

Asia‐Pacific Economic History Review, Volume 65, Issue 1, Page 3-38, March 2025.
Abstract China's center of socioeconomic activities was in the North prior to the Tang dynasty but is in the South today. We demonstrate that Arab and Persian Muslim traders triggered that transition when they came to China in the late seventh century, by lifting maritime trade along the South Coast and re‐creating the South.
Zhiwu Chen, Zhan Lin, Kaixiang Peng
wiley   +1 more source

Testing the Effects of Personality-Related Beliefs on Micro-PK

Publication to this project: Jakob, M.-J., Dechamps, M., & Maier, M. (2024). Testing the Effects of Personality-Related Beliefs on Micro-PK. Journal of Anomalous Experience and Cognition, 4(1), 34–59.
Marissa Jakob, Moritz Dechamps
core   +2 more sources

Clinical Outcomes of the POPCORN Study: Pharmacodynamics of Pre‐Operative PD1 CheckpOint Blockade and Receptor Activator of NF‐κB Ligand (RANKL) Inhibition in Non‐Small Cell Lung Cancer (NSCLC)—A Phase 1B/2 Trial

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Expanding on the growing evidence for neoadjuvant immunotherapy in resectable non‐small cell lung cancer, this study explored neoadjuvant nivolumab ± denosumab. Two of the 10 treated patients achieved a pathological complete response. CD8 T‐cell infiltration correlated with pathological response, warranting ongoing translational research to understand ...
Elizabeth Ahern, Cassie Turner, Rishendran Naidoo, David Godbolt, Amy Ives, Kirsten Popplewell, Zarnie Lwin, Sally Pearson, Kimberley Nelson, Jason Madore, William C Dougall, Brett G. M. Hughes   +11 more
wiley   +1 more source

Making the Case for Organ-on-Chip Platforms in Long-Acting Therapeutics Development. [PDF]

Adv Healthc Mater
Gowans C, Khedr A, Georgiou PG, Arik N, Sen O, Rannard SP, McDonald TO, Tapeinos C.   +7 more
europepmc   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

The value of target-site physiologically-based pharmacokinetics for high-affinity small molecules: a mechanistic foundation for precision dosing in oncology and hematology. [PDF]

Cancer Chemother Pharmacol
van der Gaag S, Oprea-Lager DE, Vis AN, Hendrikse H, Bartelink IH.   +4 more
europepmc   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Benchmarking p<i>K</i>_a Prediction Algorithms against an Extensive, Public Data Set. [PDF]

J Chem Inf Model
Sipos-Szabó L, Bajusz D, Balogh GT, Keserű GM.   +3 more
europepmc   +1 more source