Results 181 to 190 of about 990,521 (271)

Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner, Véronique Dehlinger, Patrick Rodriguez, Kerstin Fabbri, Yvan Varisco, Matteo Pigni, Alessandra Lovison, Lucas Münzenmaier, Kasia Piorkowska, Aline Fuchs, Nadine Ait‐Bouziad, Nicolas Fournier, Sandra Jepaul, Jérôme Molette, Emanuele Gabellieri, Vincent Darmency, Sonia Poli, Andrea Pfeifer, Marie Kosco‐Vilbois, Francesca Capotosti   +19 more
wiley   +1 more source

Monotherapy with PHMB 0.08% as "Switch Treatment" in Complex Cases of Acanthamoeba Keratitis: A Report of Two Cases. [PDF]

Case Rep Ophthalmol
Chatzimichail E, Stasik I, Steinemann A, Blaser F, Gatzioufas Z.   +4 more
europepmc   +1 more source

Inside a duck‐billed dinosaur: Vertebral bone microstructure of Huallasaurus (Hadrosauridae), Upper Cretaceous of Patagonia

The Anatomical Record, Volume 309, Issue 7, Page 1702-1712, July 2026.
Abstract Dinosaurs evolved a unique respiratory system with air sacs that contributed to their evolutionary success. Postcranial skeletal pneumaticity (PSP) has been used to infer the presence of air sac systems in some fossil archosaurs. While unambiguous evidence of PSP is well documented in pterosaurs and post‐Carnian saurischians, it remains absent
Tito Aureliano, Aline M. Ghilardi, Jonatan Kaluza, Agustín G. Martinelli   +3 more
wiley   +1 more source

Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth. [PDF]

ACS Pharmacol Transl Sci
Milhm GP, Moreira FL, Abrahim-Vieira BA.
europepmc   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Discovery and characterization of canvuparatide, a once-weekly parathyroid hormone analog for the treatment of hypoparathyroidism. [PDF]

Mol Metab
Zhang F, Perez-Tilve D, Allen MR, Metzger CE, Dorato MA, Geiger MJ, DiMarchi RD.   +6 more
europepmc   +1 more source

Zinc Oxide Nanoparticles for Food Applications: From Synthesis and Functional Properties to Safety and Sustainability

Food Frontiers, Volume 7, Issue 4, July 2026.
Green and conventional synthesis routes produce ZnO nanoparticles with tunable physicochemical properties for food applications, ZnO‐NPs enhance antimicrobial activity, UV protection, and food preservation through ROS generation and ZN2+ release. However, particle dissolution, migration, cytotoxicity, and environmental concerns highlight the need for ...
Liza Akter, Md. Hassan Bin Nabi, Yusuf Chowdhury, Mohima Akther Any, Md Abu Rayhan, Abid Hassan Arnab, Wahidu Zzaman   +6 more
wiley   +1 more source

Interpersonal Predictors of Grief Among Caregivers of Persons With Dementia. [PDF]

Am J Geriatr Psychiatry
Owens L, Prigerson HG, Falzarano FB, Maciejewski PK.   +3 more
europepmc   +1 more source

Inference on C_{pk} index through Monte Carlo simulation

reservedProcedura inferenziale sull'indice C_{pk} ottenuto mediante simulazione Monte Carlo, con annessa implementazione in R del procedimento ed esempi pratici per verificarne l ...
TONELLATO, ANDREA
core  

Specific Deletion of Interleukin‐1 Beta in Microglia Improves Acute Outcome and Modulates Neurogenesis After Ischemic Stroke

Glia, Volume 74, Issue 7, July 2026.
Microglial IL‐1β deletion improves acute outcome and reduces neutrophil recruitment after experimental ischemic stroke. Microglial IL‐1β deletion increases neurogenesis in the subventricular zone after experimental ischemic stroke. ABSTRACT Interleukin‐1 (IL‐1) signaling is a major driver of post‐ischemic neuroinflammation, yet the cell‐ and isoform ...
Alba Grayston, Margarida Baptista, Kelly Wemyss, Ruby Taylor, Grace Cullen, Syeda S. Jafree, Nadim Luka, Joshua R. Cox, Joanne E. Konkel, David Brough, Stuart M. Allan, Emmanuel Pinteaux   +11 more
wiley   +1 more source